中国组织工程研究与临床康复2008，Vol.12Issue(23)：4591-4593,3.
壳聚糖-聚羟基丁酸酯接枝共聚物的制备与表征
Preparation and characterization of chitosan-g-poly (3-hydroxybutyrate) copolymer
摘要
Abstract
BACKGROUND: Chitosan/poly (3-hydroxybutyrate) (PHB) copolymer has been paid close attention for special biological source of Chitosan and PHB. However, there has been no proper method for them to polymerize effectively.OBJECTIVE: To prepare chitosan/PHB graft copolymer in a homogeneous medium, using a gentle initiator.DESIGN, TIME and SETTING: This study, a single-sample experiment, was performed at the Research Center of Chemistry, Xi'an University of Architecture and Technology, Xi'an, Shaanxi Province, China from August 2007 to October 2007.MATERIALS: Chitosan: DD=100%, Mη=123000, Kyoto, Japan. PHB was purchased from Aldrich chemicals and the molecular weight was 10000.METHODS: Chitosan was grafted with poly (3-hydroxybutyrate) (PHB) in acetic acid/dimethyl sulfoxide system, and benzoyl peroxide (BPO) was used as initiator. The reaction temperature was 85℃ and the reaction continued for 5 hours with nitrogen protection. Grafting reaction and the chemical structure of the copolymer were confirmed by infrared analysis, NMR and elemental analysis. The crystal form and thermal stability of copolymer were characterized with wide-angel X-ray diffraction (WAXD) and thermogravimetric/differential thermal analysis balance, respectively.MAIN OUTCOME MEASURES: The chemical structure of copolymer, crystal form as well as thermal stability.RESULTS: Grafting reaction was confirmed by infrared analysis, NMR and elemental analysis. Wide angle X-ray diffraction and thermogravimetric analysis indicated that graft copolymer was different from chitosan and PHB in crystalline morphology, and had a good thermal stability.CONCLUSION: Using BPO as initiator, chitosan/PHB grafting copolymer is prepared and it has a steady property.关键词
壳聚糖/聚羟基丁酸酯/壳聚糖-g-聚羟基丁酸酯/接枝共聚物分类
医药卫生引用本文复制引用
孟晓荣,杨晓光,张敏..壳聚糖-聚羟基丁酸酯接枝共聚物的制备与表征[J].中国组织工程研究与临床康复,2008,12(23):4591-4593,3.基金项目
国家自然科学基金资助(50673056):生物降解材料的降解速度可控及循环再利用的机理研究 the National Natural Science Foundation of China, No. 50673056 （50673056）
