广东医学2001，Vol.22Issue(6)：459-462,4.
吸烟、饮酒的糖尿病危险性分析
Cigarette smoking, alcohol use, and the risk of diabetes in Guangdong population
摘要
Abstract
Objective To examine the association between smoking, alcohol consumption and the risk of diabetes and the impacts of smoking and alcohol on postprandial plasma glucose(PG), blood pressure, body mass index(BMI) and waist-to-hip ratio(WHR) in patients with diabetes and IGT.Methods Data from 1998 Guangdong provincial diabetes interview survey, a population-based cross-sectional study including. 11 767 residents aged 20～74 years［male 5 462, female 6 305,mean age (43.8±13.6) years］, was used for analysis. Standard oral glucose tolerance test(75 g) and physical examination were conducted on all subjects. Questionnaire included questions about physical activity, family history, economic state, average daily consumption of alcohol and cigarette, etc. Multivariate logistic regression and GLM-General factorial analysis were used. Results In Guangdong population, the main independent predictive factors of diabetes were age (OR=2.053, 1.568～2.687), family history (OR=3.210, 2.019～5.104), exercise (OR=1.644, 1.217～2.221), BMI(OR=2.538, 1.905～3.381), WHR(OR=2.255,1.690～3.008) and hypertension(OR=3.088, 2.246～4.245). Affer adjusted for age, physical activity, family history and economic state, the odds ratio of smoking＞25 cigarettes a day was 1.037(0.367～1.535), drinking＞7 times per week was 1.261(0.718～2.214); but there were significant interaction between smoking or drinking and age, family history or exercise condition, after controlling for confounders, the odds ratios of diabetes were 3.910(1.953～7.826) for smoking＞25 cigarettes a day and age＞50 years, 2.251(1.144～4.431) for smoking＞25 cigarettes a day and lower physical activity, 2.421(1.130～5.185) for drinking＞7 times per week and age＜50 years, 8.608(2.140～34.631) for drinking＞7 times per week with family history. Among the patients with diabetes or IGT, current smoking had higher WHR but lower BMI than never and ever smoker, current drinker only had lower BMI than ever drinker. Conclusion Either heavy smoking or drinking may be a dependent, modifiable risk factor for diabetes in Guangdong population. It has significant interaction with other independent risk factor for diabetes in Guangdong population. It has significant interaction with other independent risk factors-age, family history and physical activity. Smoking may lead to abnormal body fat distribution in diabetes and IGT.关键词
吸烟/饮酒/糖尿病/危险因素分类
医药卫生引用本文复制引用
广东省糖尿病流行病学调查协作组,邝建,杨华章,崔炎棠..吸烟、饮酒的糖尿病危险性分析[J].广东医学,2001,22(6):459-462,4.基金项目
广东省科委重点攻关资助课题(编号：A000097152) （编号：A000097152）
