河北北方学院学报(医学版)2009，Vol.26Issue(4)：4-6,3.
肾上腺素对离体豚鼠左心室流出道组织自律性电活动的影响
Electrophysiological Effects of Epinephrine on Pacemaker Cells in Guinea-pig Left Ventricular Outflow Tract
摘要
Abstract
Objective:To explore the effects of epinephrine(E)on spontaneous slow action potentials（APs）of guinea-pig left ventricular outflow tract cells.Methods:By using standard intracellular microelectrode technique to record APs,E was used to investigate the electrophysiological features of left ventricular outflow tract cells.Electrophysiological parameters examined were:maximal diastolic potential(MDP),amplitude of action potential(APA),maximal rate of depolarization(Vmax),velocity of diastolic depolarization(VDD),rate of pacemaker firing(RPF),50% and 90% of duration of action potential(APD50 and APD90).Results:The results obtained were as follows:Application of 100μmol/L E resulted in a significant increase in VDD(P<0.05),RPF(P<0.01),APA(P<0.05)，MDP(P<0.05)and Vmax(P<0.05);a notable shorteness in and APD90(P<0.01)in the pacemaker cells.Conclusion:These results suggested that E should excite the pacemaker cells of left ventricular outflow tract.关键词
肾上腺素/电生理学技术/心脏/豚鼠/左心室流出通/自律细胞Key words
Epinephrine/Electrophysiology Techniques/Cardiac/Guinea Pigs/Left Ventricular outflow Tract/Pacemaker Cells分类
医药卫生引用本文复制引用
陈立锋,徐涛,范凌,陈少峰,孙琳,尹万斌,赵兰平..肾上腺素对离体豚鼠左心室流出道组织自律性电活动的影响[J].河北北方学院学报(医学版),2009,26(4):4-6,3.基金项目
河北省教育厅自然科学研究项目(编号:2005312) （编号:2005312）
