江苏大学学报（医学版）2008，Vol.18Issue(6)：461-465,5.
转录产物MALA1的高表达:与早期非小细胞型肺癌的转移有关
High expression of the transcript MALA1: association with metastasis of early stage non-small cell lung cancer
摘要
Abstract
Objective: To investigate the relationship of the expression level of the transcript MALA1 and the metastasis of early stage non-small cell lung cancer(NSCLC).Methods： Expression level of MALA1 was analyzed with real time quantitative PCR in 70 patients of NSCLC.Results： In the study of an over five-year follow-up for stage Ⅰand Ⅱ NSCLC patients.It was found that the death rate was more than 40% in patients with high MALA1 expression, whereas only 9%(2/22) in patients with low MALA1 expression died(P=0.01), suggesting high expression of MALA1 was potentially predictive for a poor prognosis in early NSCLC.Additionally, it was found that the association of MALA1 gene with metastasis depended on the tumor′s histology.Conclusion： These results demonstrated that MALA1 transcript could be used as a biological marker, which may predict high risk for the development of distant metastasis and could be further helpful in improvement of treatment for early-stage NSCLC patients.关键词
转移/非小细胞型肺癌/MALA1/表达/扣除杂交Key words
metastasis/non-small cell lung carcinoma/MALA1/expression/subtractive hybridization分类
医药卫生引用本文复制引用
王文兵,周密,严丽荣,乌慧玲..转录产物MALA1的高表达:与早期非小细胞型肺癌的转移有关[J].江苏大学学报（医学版）,2008,18(6):461-465,5.基金项目
This work was supported by Open Fund of Key Laboratory of Oncogenes, Shanghai Cancer Institute(80-07-02). （80-07-02）
