中华医学杂志（英文版）2003，Vol.116Issue(3)：462-464,3.
The role of CTLA4-Ig in a mouse model against allergic asthma
The role of CTLA4-Ig in a mouse model against allergic asthma
万欢英 1周敏 1徐青 1黄绍光 1邓伟吾1
作者信息
- 1. Department of Respiratory Medicine, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
- 折叠
摘要
Abstract
Objective To investigate CTLA4-Ig's potential role in therapy for allergic asthma by blocking B7/CD28 interactions with cytotoxic T lymphocyte antigen 4-Ig (CTLA4-Ig).Methods We divided BALB/C mice into the three groups: Sham/Sham (control), ovalbumin (OVA)/OVA and mCTLA4-Ig. Blood, bronchoalveolar lavage, histology and determination of cytokines were performed 24 hours after airway challenge. Results In the OVA/OVA group, the number of cells, the percentage of inflamed cells and the level of IL-4 in BALF were increased. Airways in our murine model for allergic asthma underwent pathological changes, which were significantly reduced after treatment with mCTLA4-Ig. Conclusion Blockage of co-stimulation with mCTLA4-Ig can inhibit allergy-specific response of T cells, and asthmatic response as well.关键词
CTLA4-Ig/asthma, allergicKey words
CTLA4-Ig/asthma, allergic分类
医药卫生引用本文复制引用
万欢英,周敏,徐青,黄绍光,邓伟吾..The role of CTLA4-Ig in a mouse model against allergic asthma[J].中华医学杂志（英文版）,2003,116(3):462-464,3.
