青岛海洋大学学报2000，Vol.30Issue(3)：463-469,7.
海洋硫酸多糖DPS对肾血管性高血压大鼠的降压作用
Antihypertensive Effects of D-polymannuronic Sulfate in Renovascular Hypertensive Rats (Series Ⅰ)
摘要
Abstract
To investigate the antihypertensive effects of D-polymannuronic sulfate (DPS) in renovascular hypertensive rats (RHR) ［two-kidney one clip, Goldblatt (2-K 1C)］, the effect of a single injection of DPS at doses of 1.56, 3.13, 6.25, 12.50 and 25.00 mg/kg was studied in renovascular hypertensive rats in the acute therapeutic experiment. While in the prophylactic experiment，the effects of DPS given orally at doses of 12.50, 25.00 and 50.00 mg/kg once a day for five weeks simultaneously with the initiation of the establishment of the renovascular hypertensive model were evaluated. In the acute therapeutic experiment, DPS markedly reduced systolic blood pressure (SBP) and diastolic blood pressure (DBP) in DPS-treated RHR dose-dependently, and decreased heart rate with the reduction in arterial blood pressure. In the prophylactic experiment, DPS prevented the rise in SBP and DBP in the RHR with DPS administration in a dose-dependent manner in comparison with that of the RHR without DPS administration, and DPS at a dose of 50 mg/kg bore a similarity in hypotensive potency to that of captopril (14 mg/kg). These results indicated that DPS exerted antihypertensive activities dose-dependently in renovascular hypertensive rats.关键词
海洋硫酸多糖(DPS)/降压作用/肾血管性高血压大鼠Key words
marine D-polymannuronate sulfate (DPS)/antihypertensive effect/renovascular hypertensive rats分类
医药卫生引用本文复制引用
朱海波,耿美玉,管华诗..海洋硫酸多糖DPS对肾血管性高血压大鼠的降压作用[J].青岛海洋大学学报,2000,30(3):463-469,7.基金项目
国家"九五"科技攻关项目 (96-C-02-04-01)资助 Supported by National Ninth-Five Year Plan Key Project Foundation (No.96-C 02-04-01) （96-C-02-04-01）
