生殖医学杂志2007，Vol.16Issue(z1)：46-51,6.
Sequence alterations of the whole mitochondrial genome in primary and recurrent ovarian carcinomas
Sequence alterations of the whole mitochondrial genome in primary and recurrent ovarian carcinomas
摘要
Abstract
Objective: To investigate mitochondrial DNA (mtDNA) alterations in primary and recurrent ovarian carcinomas to illuminate the impact of chemotherapy on mtDNA.Methods.Complete mtDNA genomes of tumor tissue from 7 pimary ovarian carcinoma patients without treatment and 9 recurrent ones with prior chemotherapies were sequenced as well as their matched normal tissue.MtDNA alterations, including somatic mutations and new polymorphisms and consequent amino-acid alterations were compared between the two groups.Results, A large number of mtDNA new polymorphisms (69) and somatic mutations (17) were found in 16 ovarian carcinoma samples.Chemotherapy might not lead to more, heteroplasmic mutations and consequent aminoacid alterations (P＞0.05) in the recurrent ovarian carcinoma patients than in the untreated ones.Conclusions: MtDNA damage was not so certainly made by chemotherapies and some of the mtDNA defects might be part of the disease process rather than a consequence of treatment.关键词
Ovarian carcinomas/ Mitochondrial genome/ Somatic mutations/Polymorphisms/ Homoplasmic/ Heteroplasmic.CLC numbeer:R711.75Key words
Ovarian carcinomas/ Mitochondrial genome/ Somatic mutations/Polymorphisms/ Homoplasmic/ Heteroplasmic.CLC numbeer:R711.75分类
医药卫生引用本文复制引用
Shi Hong-hui,Song Tian,Pan Ling-ya..Sequence alterations of the whole mitochondrial genome in primary and recurrent ovarian carcinomas[J].生殖医学杂志,2007,16(z1):46-51,6.基金项目
National Natural Science Foundation of China （）
Code: 30271357 （）
