中国临床康复2004，Vol.8Issue(22)：4654-4656,3.
中国北方汉族人体MTHFR和CBS基因多态性与脑梗死及脑出血遗传相关性的研究
Correlation of polymorphism of gene methylenetetrahydrofolate reductase and cystathionine beta-synthase with heredity of cerebral infarction and cerebral hemorrhage in northern Chinese Han people
方乐 1邬英全 1王田蔚2
作者信息
- 1. 吉林大学中日联谊医院神经内科,吉林省长春市,130031
- 2. 吉林大学中日联谊医院放射线科,吉林省长春市,130031
- 折叠
摘要
Abstract
BACKGROUND: It is controversial on whether the gene methylenetetrahydrofotate reductase(MTHFR) and cytathionine beta-synthase(CBS) are the susceptible genes of cerebrovascular diseases.OBJECTIVE: To study the correlation between polymorphism of gene MTHFR and CBS and heredity of cerebral infarction and hemorrhage.DESIGN: A case-control study.SETTINGS and PARTICIPANTS: Fifty-four patients with cerebral infarction(cerebral infarction group), 27 patients with cerebral hemorrhage (cerebral hemorrhage group) and 96 healthy people(control group) were selected from the Han nationality population in northern China.INTERVENTION: Method of restriction fragment length polymorphism (PCR-RFLP) was used to detect the C677T polymorphism of gene MTHFR and T27796C of gene CBS.MAIN OUTCOME MEASURES: PCR-RFLP results of gene MTHFR and CBS; genotypes of MTHFR and CBS of three groups as well as the frequency distribution of allclomorphic gene.RESULTS: C667T of gene MTHFR had significant correlation with cerebral infarction and hemorrhage. There was difference (x2 = 5. 28, 4.69, P ＜0.05) on allele frequency of T/C among infraction group(47.2% ),hemorrhage group(44.4% ) and control group(60. 9% ). There was higher risk for allelotype TT suffering from cerebral infraction, hemorrhage than type CC( OR = 2.53, OR = 3.0) . There was no clear correlation between T27796C of gene CBS and cerebral infraction and hemorrhage( P ＞0. 05).CONCLUSION: There is correlation between mutable site C667T of gene MTHFR and cerebral infraction and hemorrhage. MTHFR is more likely a susceptible gene for cerebral apoplexy. There is no association between polymorphism T27796C of gene CBS with cerebral infraction and hemorrhage.关键词
脑梗塞/遗传学/脑出血/遗传学/亚甲基四氢叶酸还原酶/胱硫醚β合成酶/多态性/限制性片段长度分类
医药卫生引用本文复制引用
方乐,邬英全,王田蔚..中国北方汉族人体MTHFR和CBS基因多态性与脑梗死及脑出血遗传相关性的研究[J].中国临床康复,2004,8(22):4654-4656,3.
