中华医学杂志（英文版）2003，Vol.116Issue(3)：469-471,3.
Clinical significance of serum cardiac troponin T in patients with congestive heart failure
Clinical significance of serum cardiac troponin T in patients with congestive heart failure
薛春才 1于宏伟 2李瑞杰 3沃金善 4崔家玉 1程海宾 1王洪云 1管庆华 1索晓霞 1贾荣波1
作者信息
- 1. Department of Cardiology, People's Hospital of Binzhou city, Shandong 256610, China
- 2. Department of Endocrinology and Diabetes and Human Genetics, Medical University of South Carolina, 29407 USA
- 3. Department of Cardiology, Chuiyangliu Hospital of Beijing, Beijing, China
- 4. Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao 266003, China
- 折叠
摘要
Abstract
Objective To determine whether the level of serum cardiac troponin T (cTnT) was increased in patients with congestive heart failure (CHF). Methods This study consisted of 265 patients with CHF and 75 healthy people. Serum cTnT was measured by electrochemiluminescence immunoassay using an Elecsys 1010 automatic analyzer. Results cTnT concentration was 0.181±0.536 ng/mL in CHF patients and 0.003±0.001 ng/mL in controls (P<0.001). Patients were categorized according to the levels of heart function and left ventricular ejection fraction (LVEF). In the first group consisting of 105 patients with LVEF≤35%, cTnT was 0.311±0.221 ng/mL. In the second group of 106 patients with LVEF>35%, cTnT was 0.07±0.0 5ng/mL (P<0.01). In patients with NYHA class Ⅰ, Ⅱ, Ⅲ and Ⅳ, cTnT values were 0.062±0.022 ng/mL, 0.113±0.121 mg/mL, 0.191±0.231 mg/ml and 0.384±0.211 mg/mL, respectively (class Ⅰ vs class Ⅱ P>0.05, class Ⅱ vs class Ⅲ P<0.01, class Ⅲ vs class Ⅳ P<0.01). A negative correlation was observed between serum cTnT concentration and LVEF in 265 patients with CHF (r=-0.493, P<0.001).Conclusions This study shows that the level of serum cTnT is increased in patients with CHF and that the increased level indicates the severity of CHF.关键词
troponin T/congestive heart failure/necrosisKey words
troponin T/congestive heart failure/necrosis分类
医药卫生引用本文复制引用
薛春才,于宏伟,李瑞杰,沃金善,崔家玉,程海宾,王洪云,管庆华,索晓霞,贾荣波..Clinical significance of serum cardiac troponin T in patients with congestive heart failure[J].中华医学杂志（英文版）,2003,116(3):469-471,3.
