中德临床肿瘤学杂志（英文版）2009，Vol.8Issue(8)：471-475,5.DOI:10.1007/s10330-009-0104-9
三阴性乳腺癌患者的临床特征与预后分析
Clinical characteristics and prognosis of triple-negative breast cancer
摘要
Abstract
Objective: We investigated the clinical characteristics, and the prognostic factors of triple-negative breast can-cer. Methods: 130 triple-negative breast cancer patients were reviewed on clinical characteristics and prognosis. All cases were lack of expression of estrogen receptor, progesterone receptor, and HER2/neu determined by immunohistochemistry.Results: 17.1% of all breast cancer patients (774 cases) were triple-negative breast cancer, and 68.9% of triple-negative breast cancer patients (91 cases) were premenopausal. 53.8% of patients (71 cases) had the tumors with T2 size, and 39.4% of them (52 patients) had lymph node metastasis. The rate of relapse in patients with lymph node metastasis was obviously higher than that in patients without lymph node metastasis (P = 0.001). The median time of follow-up was 63 months. 33 cases relapsed and 20 patients died. 23 patients had at least two organs metastasis. The 5-year disease-free and overall survival rates were 73.8% and 85.7%. Conclusion: Triple-negative breast cancer patients commonly have high rate of multiple distant metastasis in 2-3 years after treatment. The status of lymph node is the most important prognostic factor. The triple-negative breast caner patients with lymph node metastasis have poor prognosis.关键词
triple-negative breast cancer/clinical characteristics/prognosisKey words
triple-negative breast cancer/clinical characteristics/prognosis分类
医药卫生引用本文复制引用
Hua Cao,Maosheng Yan,Shubin Wang,Tao Zheng,Rulian Xu,Yixin Chen,Yajie Liu..三阴性乳腺癌患者的临床特征与预后分析[J].中德临床肿瘤学杂志（英文版）,2009,8(8):471-475,5.基金项目
a grant from the Medical Research Foundation of Guang-dong Province (No. 2006576). （No. 2006576）
