现代妇产科进展2000，Vol.9Issue(6)：474-477,4.
Uterine papillary serous carcinoma:Its clinical and fundamental study
Uterine papillary serous carcinoma:Its clinical and fundamental study
摘要
Abstract
Uterine papillary serous carcinoma (UPSC) was established as a distinct type of endometrial carcinoma by Lauchlan in 1981 and Hendrickson et al in 1982, and accounted for 1% ～ 10% of endometrial cancers. Theoccurencer of papillary patterns of endometrial adenocarcincma had been reportedly recognized since 1900, while until the late 1970s several authors have had described a variant of papillary endometrial cancer. UPSC is a morphologically unique variant of endometrial carcinoma that is pathologically defined by the presence of high nuclear grade, distinct papillary architechtural changes, psammoma bodies, and extensive lymph- vascular space invasion. CA125 is often mentioned a usefultumor marker either for diagnosis before starting treatment or in monitoring recurrence. The ptimal treatment of UPSC is controversial and appears to be dependent upon the stage of the disease. Primary surgery comprised of TAH/BSO and complete staging is the mainstay of treatment. The patients with recurrent UPSC in many studies were treated with various combinations of surgery, radiation therapy, and chemotherapy. The molecular basis for the general poor response of UPSC to adjuvant chemotherapy and radiotherapy is not well understood. UPSC tumors are more often aneuploid and contain overexpressed mutant p53 protein as compared to encdometrioid adenocarcinoma. Unlike patients with adenocarcinoma of the endomeutrium, women with UPSC were less likely to be obese, hypertensive, or diabetic.关键词
Uterine neoplasms/Uterine papillary serous carcinoma/Drug therapy/Radiotherapy/Surgery, gynecologicKey words
Uterine neoplasms/Uterine papillary serous carcinoma/Drug therapy/Radiotherapy/Surgery, gynecologic引用本文复制引用
..Uterine papillary serous carcinoma:Its clinical and fundamental study[J].现代妇产科进展,2000,9(6):474-477,4.基金项目
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