中国药理学与毒理学杂志2001，Vol.15Issue(1)：47-50,4.
4-磺酸酯-2，2，6，6-四甲基哌啶氮氧自由基对大鼠组织和 红细胞的抗脂质过氧化作用
Antioxidative activity of 4-sulfonate-2,2,6,6-tetramethylpiperidi- neoxyl in tissues and erythrocytes from rats
葛斌 1陈立德 1张振明1
作者信息
- 1. 甘肃省人民医院药剂科， 甘肃 兰州 730000
- 折叠
摘要
Abstract
The effect of antioxidation of4-sulfonate-2,2,6,6-tetramethylpiperidineoxyl (STMP) in tissues and erythrocytes from rats were studied by determining malondialdehyde (MDA) formation induced by .OH free radical generation system (Fe2+-ascorbic acid) in homogenate of heart, liver and kidneys of rats using thiobarbituric acid colorimetric method, by measuring spectrometrically H2O2-caused hemolysis and by assaying superoxide anion from zymosan-stimulated neutrophils of rats. The results showed that STMP markedly inhibited MDA generation caused by .OH generation system with IC50 value 4.4(in heart), 3.2(in liver) and 3.7(in kidneys) μmol.L-1, respectively, antagonized H2O2-caused hemolysis (IC50=318 μmol.L-1), but did not affect O2÷ formation from activated neutrophils. It is suggested that STMP exert their antilipoperoxidative effect by specifically scavenging .OH free radicals and H2O2 in biological system.关键词
4-磺酸酯-2,2,6,6-四甲基哌啶氮氧自由基/自由基/丙二醛/中性白细胞/红细胞分类
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葛斌,陈立德,张振明..4-磺酸酯-2，2，6，6-四甲基哌啶氮氧自由基对大鼠组织和 红细胞的抗脂质过氧化作用[J].中国药理学与毒理学杂志,2001,15(1):47-50,4.
