生殖医学杂志2003，Vol.12Issue(z1)：47-50,4.
Analysis of anti-zona pellucida antibody and tumor necrosis factor-α,γ-interferon and interleukin-2 in sera from patients with premature ovarian failure
Analysis of anti-zona pellucida antibody and tumor necrosis factor-α,γ-interferon and interleukin-2 in sera from patients with premature ovarian failure
王一峰 1韩兰英 1欧汝强 1杨宁 1谢端薇 1陈巧儿1
作者信息
- 1. Family Planning Research Institute of Guangdong,Guangzhou,510600,China
- 折叠
摘要
Abstract
Objective:To investigate the role and the clinical significance of anti-zona pellucidaantibody (AzpAb) and tumor necrosis factor-α(TNF-α),γ-interferon(IFN-γ) and inter-leukin-2 (IL-2) in sera from patients with premature ovarian failure (POF).Methods: The AzpAb in the serum of POF patient was analyzed by means ofELISA. The levels of TNF-α, IL-2 and IFN-γ in the serum were determined by meansof radioimmunoassay (RIA).Results:The level of serum AzpAb in the POF patients was significantly higher thanthat of the normal controls(P＜0.001). The levels of TNF-α and IL-2 were significantlyreduced (P＜0. 001), and the level of IFN-γ was significantly elevated (P＜0.01). Thelevels of above three cytokines in AzpAb positive group were significantly higher thanthose of the negative group in POF patients.Conclusion: This study suggested that AzpAb, TNF-α, IFN-γ and IL-2 might playimportant roles in the pathogenesis of autoimmune POF.关键词
Premature ovarian failure/Anti-zona pellucida antibody/Tumornecrosis factor-α/Interferon-γ/Interleukin-2Key words
Premature ovarian failure/Anti-zona pellucida antibody/Tumornecrosis factor-α/Interferon-γ/Interleukin-2引用本文复制引用
王一峰,韩兰英,欧汝强,杨宁,谢端薇,陈巧儿..Analysis of anti-zona pellucida antibody and tumor necrosis factor-α,γ-interferon and interleukin-2 in sera from patients with premature ovarian failure[J].生殖医学杂志,2003,12(z1):47-50,4.
