北京大学学报（医学版）2004，Vol.36Issue(1)：47-51,5.
清醒大鼠前扣带皮层神经元群的伤害性反应
Nociceptive responses of anterior cingulate cortical ensembles in behaving rats
摘要
Abstract
Objective: To confirm the role of anterior cingulated cortices (ACC) in the coding of pain affect by exploring the neural ensemble coding pattern within the anterior cingulate cortex in behaving rats with a multichannel recording technique. Methods: In five adult male Sprague-Dawley rats, two arrays of eight stainless steel microwires were bilaterally implanted into ACC. Noxious radiant heat stimulation was applied to the tail, bilateral fore-paws and hind-paws of freely moving rats. Neuroelectric signals were obtained from the microwires and sent to a multichannel recording device via cables and connectors. The time stamps of neuronal activities were stored on a personal computer for off-line analysis. Results:Noxious heat stimuli evoked predominantly excitatory and sustained neural activity within ACC, reflecting the processing of pain unpleasantness; pain-related anticipatory responses could be seen near the stimulation start, indicating the behavioral preparation for escape; ACC neurons had broad receptive fields by showing quite similar pain-related responses to stimuli on either side of the hind-paw, suggesting that they are not eligible for the localization of a stimulus. Conclusion: ACC has played a major role in processing the affective-motivational aspect of pain.关键词
情绪/扣带皮层/神经元/疼痛Key words
Emotion/Cingulate cortex/Neurons/Pain分类
医药卫生引用本文复制引用
王锦琰,罗非,张含荑,张景渝,Donald J.WOODWARD,韩济生..清醒大鼠前扣带皮层神经元群的伤害性反应[J].北京大学学报（医学版）,2004,36(1):47-51,5.基金项目
国家自然科学基金(30170307) ,教育部教育振兴行动计划特殊专项("九八五"工程),国家"211工程"学科建设项目资助 （30170307）
