口腔颌面外科杂志2001，Vol.11Issue(1)：49-52,56,5.
颊粘膜鳞癌中p27Kipl基因的蛋白质表达及临床意义
CLINICAL SIGNIFICANCE AND EXPRESSION OF p27Kipl IN BUCCAL MUCOSA SQUAMOUS CELL CARCINOMA
汤炜 1王炼 1李声伟 1田卫东 1魏于全 1杨橙1
作者信息
摘要
Abstract
Objective To study the relationship between the expression of p27tumor s uppressor gene and clinical pathological characteristics or prognosis of buccal mucosa squamous cell carcinoma (BMSC). Methods The expression of p27 in 40 BMSC, 20 leukoplakia, 7 normal oral mucosa specimens was detected by immunohistochemical method. The relation b etween p27 expression and clinicopathological characteristics or survival time w as analyzed by χ2 test or log rank test, respectively, while univariate and mutivariate prognostic analyses were performed by using Cox's regression model. Results p27 protein staining was confined to the nucleus and (or) cytoplasm. All of normal oral mucosa and leukoplakia without epithelial dysplasi a showed strong expression, leukoplakia with epithelial dysplasia and high-diff erentiation BMSC were also detected, but low-differentiation often not express ed (P<0.05). The high p27 expression in BMSC was 52.5%(21/40). Low p27 expre ssion in BMSC was significantly associated with high incidence of lymph node met astasis, local recurrence and distant metastasis (P<0.05). Log rank test sho wed that the p27 expression was positively correlated with survival time and Cox 's regression indicated that p27 was a prognostic marker of BMSC. Conclusion Low p27 expression was associated with increasing lymph node and distant metastasis and resulted in a poor prognosis with BMSC. So we c oncluded that assessment of p27 expression was useful as a prognostic factor fo r BMSC and in selecting aggressive therapy.关键词
颊粘膜鳞癌/p27Kipl/免疫组织化学/预后分类
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汤炜,王炼,李声伟,田卫东,魏于全,杨橙..颊粘膜鳞癌中p27Kipl基因的蛋白质表达及临床意义[J].口腔颌面外科杂志,2001,11(1):49-52,56,5.
