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Increased expression of osteoprotegerin in vascular smooth muscle cells from spontaneously hypertensive rats

Yongshan MOU Tianhua LEI Luning ZHAO Xiaojun ZHU Mingui FU Yuqing E CHEN

老年心脏病学杂志（英文版）2004，Vol.1Issue(1)：49-54,6.

Increased expression of osteoprotegerin in vascular smooth muscle cells from spontaneously hypertensive rats

Yongshan MOU ¹Tianhua LEI ¹Luning ZHAO ¹Xiaojun ZHU ²Mingui FU ¹Yuqing E CHEN¹

作者信息

1. Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA
2. Cardiovascular Research Institute, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
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摘要

Abstract

Background Osteoprotegerin (OPG) is a secreted protein of the tumor necrosis factor receptor family, which regulates bone mass by inhibiting osteoclast differentiation and activation. Although OPG is expressed ubiquitously and abundantly in many tissues and cell types including vascular cells, the role of OPG in other tissues is unknown.Our previous studies demonstrated that OPG was highly expressed in vascular smooth muscle cells (VSMC) and upregulated during vascular lesion formation. Methods and Results We documented, by Northern blot analysis,that the expression of OPG was more prevalent in the aorta and cultured VSMC from spontaneously hypertensive rats (SI-IR) compared to Wistar-Kyoto rats (WKY). In addition, we found that the expression of Angiotensin II (Ang II)type I receptor (AT1R) in SHR VSMC was at significantly increased levels than in WKY VSMC. Furthermore, Ang II potently induced the expression of OPG in VSMC in a time- and dose-dependent manner through the AT1R signaling pathway. Conclusions OPG expression was substantially greater in SHR VSMC, suggesting that OPG may be an important determinant of vascular remodeling in SHR.

关键词

osteoprotegerin/hypertension/vascular smooth muscle cells/gene expression

Key words

osteoprotegerin/hypertension/vascular smooth muscle cells/gene expression

引用本文复制引用

Yongshan MOU,Tianhua LEI,Luning ZHAO,Xiaojun ZHU,Mingui FU,Yuqing E CHEN..Increased expression of osteoprotegerin in vascular smooth muscle cells from spontaneously hypertensive rats[J].老年心脏病学杂志（英文版）,2004,1(1):49-54,6.

基金项目

This work was partially supported by NIH grants (HI068878, HL03676, and S06GMO8248). （HI068878, HL03676, and S06GMO8248）

老年心脏病学杂志（英文版）

ISSN：1671-5411

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