中国现代医学杂志2004，Vol.14Issue(7)：50-52,3.
鼻塞法低负压吸出技术在COPD急性期Ⅱ型呼吸衰竭治疗中的应用
Application of aspiration with low negative pressur by nasal obstruction in patients with type Ⅱ respiratory failure in acute period of COPD
陈莉文 1肖波 1席玉胜 1徐小文 1洪伟1
作者信息
- 1. 广州海军医院呼吸内科,广东,广州,510310
- 折叠
摘要
Abstract
Objective: To evaluate the effects of aspiration with low negative pressur by nasal obstruction (NASPI) on elimination of CO2 and influence on patient's condition in patients with type Ⅱ respiratory failure in acute period of COPD. Methods: Forty type Ⅱ respiratory failure cases in acute period of COPD were averagely divided into two groups randomly;the NASPI group and the control group ,which were all treated by 25% oxygen, antibioltic and elixophylline. Using NASPI device with negative pressur of 320 ～ 400 Pa, about 1 500 ml/min of aspiration of air on the NASPI group for 2 hours, with 29% oxygen therapy by another nasal obstruction, and the patients were asked to close their mouths as possible as they could during NASPI; using Coramine 2.5 μg/min and Lobeline 20 μg/min by vein drop on the control group for 24 hours. Arterial blood gas analysis and symptom were observed at pretreatment and post -treatment. Results: NASPI significantly decreased PaCO2 level (P ＜ 0. 001 ). The elimination of CO2 of NASPI was superior to that of respiratory center stimulant. And after NASPI, patients easily cough up more phlegms. While adding to oxygen therapy, NASPI significantly increased PaO2 and SaO2. NASPI increased PH a little but not significant. At NASPI time, some patients felt laryngopharynx dry. Conclusions: NASPI is a simple, economical, safe and practical method, which can effectively decrease PaCO2 of patients with type Ⅱ respiratory failure in acute period of COPD; and after NASPI, patients cough up more phlegm easily.关键词
鼻塞法低负压吸出/COPD急性期/Ⅱ型呼吸衰竭Key words
aspiration with low ngative pessur by nasal obstruction/acute period of COPD/type Ⅱ respiratory failure分类
医药卫生引用本文复制引用
陈莉文,肖波,席玉胜,徐小文,洪伟..鼻塞法低负压吸出技术在COPD急性期Ⅱ型呼吸衰竭治疗中的应用[J].中国现代医学杂志,2004,14(7):50-52,3.
