国际医药卫生导报2009，Vol.15Issue(2)：50-52,3.DOI:DOI:10.3760/cma.j.issn.1007-1245,2009.02.020
草酸铂联合5-氟脲嘧啶和亚叶酸钙双周疗法治疗晚期大肠癌的临床观察
The clinical observation of semimonthly oxal ipclation combined with 5-fu and leucovorin in treatment of advanced colorectal cancer
梁卓林 1黄淑环 2邓叶芬 1陈安潮 1叶青华1
作者信息
- 1. 高要市人民医院526040
- 2. 肇庆市第一人民医院526021
- 折叠
摘要
Abstract
Objective To evalute the efficacy and the oxicity reaction of semimonthly oxalipclation combined with 5-Fu and leucovorin in treatment of advanced colorectal cancer．Methods Forty patients with advanced colorectal cancer received semimonthly combined chemotherapy of L-OHP(100mg／m2，iv．gtt for 2h，d1)in fusion followed by 2-hour in fusion of CF(200mg／m2，iv．gtt，d1)then intravenous bolus of 5-Fu 400mg／m2，then 48-hour infusion of 5-Fu2 500mg／m2 using an ambulatory pump．The treatment schedule was recycled every 14 days．One cycle consisted of twice chemotherapy regimens．The curative effect was evaluated two weeks later，and the response for effective patients were confirmed four weeks later．Results The total response rate was 47．5％in which CR 4 cases，PR 15cases，SD 16cases and PD 5cases of forty patients．The major toxic effects were neuro-sensory toxicity,mucositis，nausea and vomiting，bone marrow suppression etc．Conclusions Semimonthly L-
OHP combined with 5-Fu and leucovorin regimen is effective in treatment of advanced colorectal
cancer，and its toxiCity reaction is tolerable.关键词
草酸铂/5-氟脲嘧啶/亚叶酸钙/晚期大肠癌Key words
Oxalipclatiom 5-Fu/Leucovorin/Treatment of advanced colorectal cancer分类
医药卫生引用本文复制引用
梁卓林,黄淑环,邓叶芬,陈安潮,叶青华..草酸铂联合5-氟脲嘧啶和亚叶酸钙双周疗法治疗晚期大肠癌的临床观察[J].国际医药卫生导报,2009,15(2):50-52,3.
