中华医学杂志（英文版）2009，Vol.122Issue(5)：509-513,5.DOI:10.3760/cma.j.issn.0366-6999.2009.05.005
Protection of lung function by introducing single photon emission computed tomography lung perfusion image into radiotherapy plan of lung cancer
Protection of lung function by introducing single photon emission computed tomography lung perfusion image into radiotherapy plan of lung cancer
YIN Yong 1CHEN Jin-hu 2LI Bao-sheng 3LIU Tong-hai 3LU jie 3BAI Tong 3DONG Xiao-ling 3YU Jin-ming3
作者信息
- 1. Department of Biomedical Engineering, Tianjin University,Tianjin 300070, China
- 2. Department of Radiation Oncology, Shandong Tumor Hospital and
Institute, Jinan, Shandong 250117, China
- 3. Department of Radiation Oncology, Shandong Tumor Hospital and Institute, Jinan, Shandong 250117, China
- 折叠
摘要
Abstract
Background The lung functional status could be displayed on lung perfusion images. With the images, the radiotherapy plans of lung cancer could be guided to more optimized. This study aimed to assess quantitatively the impact of incorporating functional lung imaging into 3-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiation therapy (IMRT) planning for non-small cell lung cancer (NSCLC).Methods Ten patients with NSCLC who had undergone radiotherapy were included in this study. Before radiotherapy,each patient underwent CT simulation and lung perfusion imaging with single photon emission computed tomography (SPECT). The SPECT images were registered with simulation planning CT and used to contour functional lung (lung-F) and non-functional lung (lung-NF). Two 3DCRT plans and two IMRT plans were designed and compared in each patient:two anatomic plans using simulation CT alone and two functional plans using SPECT-CT in addition to the simulation CT.Dosimetric parameters of the four types of plans were compared in terms of tumor coverage and avoidance of normal tissues. Total radiation dose was set at 66 Gy (2 Gy×33 fractions).Results In incorporating perfusion information in 3DCRT and IMRT planning, the reductions on average in the mean doses to the functional lung in the functional plan were 168 cGy and 89 cGy, respectively, compared with those in the anatomic plans. The median reductions in the percentage of volume irradiated with ＞5 Gy, ＞10 Gy, ＞20 Gy, ＞30 Gy and ＞40 Gy for functional lung in the functional plans were 6.50%, 10.21%, 14.02%, 22.30% and 23.46% in 3DCRT planning,respectively, and 3.05%, 15.52%, 14.16%, 4.87%, and 3.33% in IMRT planning, respectively. No greater degree of sparing of the functional lung was achieved in functional IMRT than in 3DCRT.Conclusion Function-guided 3DCRT and IMRT plannings both appear to be effective in preserving functional lung in NSCLC patients.关键词
lung cancer/radiotherapy/lung perfusion/lung functionKey words
lung cancer/radiotherapy/lung perfusion/lung function分类
医药卫生引用本文复制引用
YIN Yong,CHEN Jin-hu,LI Bao-sheng,LIU Tong-hai,LU jie,BAI Tong,DONG Xiao-ling,YU Jin-ming..Protection of lung function by introducing single photon emission computed tomography lung perfusion image into radiotherapy plan of lung cancer[J].中华医学杂志（英文版）,2009,122(5):509-513,5.
