中德临床肿瘤学杂志（英文版）2007，Vol.6Issue(6)：514-518,5.
非小细胞肺癌术后三维适形放疗与常规放疗的疗效比较
Evaluation of conventional radiotherapy vs. conformal radiotherapy in the treatment of non-small-cell lung cancer after surgical resection
摘要
Abstract
Objective: To compare the survival fractions and radiation-induced complications of conventional radiotherapy (CV) vs. conformal radiotherapy (CF) for non-small-cell lung cancer (NSCLC) after surgical resection. Methods: Between 1990 and 2002, 167 patients underwent post-radiotherapy either CV (n = 90) or CF (n = 77) for pathological ⅢA NSCLC at the University of Texas M.D. Anderson Cancer Center. Patients and tumor characteristics were balanced in the two treatment groups. Surgical resection mainly consisted of lobectomy and mediastinal lymph node dissection. In the CV group, postoperative radiotherapy was delivered to 54.3 Gy (range 22-69.6 Gy) in 27 fractions (range 11-58 f) for 5-6 weeks, while the CF group with RT to 53.9 Gy (range 50-63 Gy) in 26 fractions (range 25-33 f) for 5-6 weeks. Overall survival, disease-free survival, local control and distant metastasis-free survival were calculated using the Kaplan-Meier method. The complications of radiotherapy were also compared between the two groups. The median follow-up duration was 36 months in the CV group while 24 months in the CF group. Results: No statistically significant differences were found in terms of disease-free survival,local-regional control and distant metastasis-free survival in the two treatment groups. However, the overall survival was found statistically significant different in the two groups (P = 0.014). Postoperative radiotherapy complications such as weight loss,skin reaction, dysphagia, and cardiac related complication were similar in the two groups although the lung fibrosis, cardiac complications and hematologic complications were significantly different, and 8 cases of death in the CV group associated with cardiac complications while none was observed in the CF group. Conclusion: The treatment of stage ⅢA NSCLC using either CV or CF postoperative radiotherapy resulted in similar outcomes in terms of local control, disease-free survival and most of complications. However, CF could achieve better overall survival and less complications such as lung fibrosis, cardiac complications and hematologic complications. The advantage is worth further observation.关键词
non-small-cell lung cancer (NSCLC)/ postoperative radiotherapy/ outcomeKey words
non-small-cell lung cancer (NSCLC)/ postoperative radiotherapy/ outcome分类
医药卫生引用本文复制引用
..非小细胞肺癌术后三维适形放疗与常规放疗的疗效比较[J].中德临床肿瘤学杂志（英文版）,2007,6(6):514-518,5.基金项目
Supported by the program "Teach the teachers" from RTOG. （）
