天津中医药2004，Vol.21Issue(6)：514-519,6.
抗菌剂合用对芍药甘草汤中甘草酸生物利用度的降低作用及减少该作用的方法Ⅲ:芍药甘草汤连续给药的回复作用
Reduction of Bioavailability of Glycyrrhizin Fim Shaoyao-Gancao-Tang by Co-administered Antibacterial Drugs and Ways of Minimizing it (Part Ⅲ) Restorative Effects of Repeated Administration of Shaoyao-Gancao-Tang
何菊秀 1谿忠人1
作者信息
- 1. 日本富山医科药科大学和汉药研究所和汉药制剂开发部门,富山,930-0194,日本
- 折叠
摘要
Abstract
In part Ⅱ, we reported that the co-administration of antibacterial drugs AMPC-MET (amoxicillin, AMPC,and metronidazole, MET) significantly decreased the bioavailability of glycyrrhizin (GL) fim Shaoyao-Gancao-Tang (SGT) ,due to their decreasing effects on the Gl-metabolizing activity of intestinal bacteria. In this part Ⅲ, the lasting time period of the influences of AMPC-MET on the GL-metabolizing activity and an appropriate medication regiment to minimize the influences were investigated. The results showed that the decreasing effects of AMPC-MET on the GL-metabolizing activity lasted for approx 12 days. However, repetitive administration of SGT starting 1 day after the treatment with AMPC-MET for 4 days significantly accelerated the recovery of the reduced plasma 18 β-glycyrrhetic acid(GA) concentration and the GL-etabolizing activity of rat feces. The present results suggest that it may be clinically useful to administer SGT repetitively starting 1 or 2 days after the antibiotic treatment during combination therapy with SGT and antibiotics to accelerate the recovery of the reduced bioavailability of GL in SGT.关键词
药物相互作用/芍药甘草汤/西药/甘草酸/药动学/肠内细菌/代谢活性Key words
drug-drug interaction/Shaoyao-Gancao-Tang/antibacterial druns/glycyrrhizin/pharmacokineties/intestinal bacteria分类
医药卫生引用本文复制引用
何菊秀,谿忠人..抗菌剂合用对芍药甘草汤中甘草酸生物利用度的降低作用及减少该作用的方法Ⅲ:芍药甘草汤连续给药的回复作用[J].天津中医药,2004,21(6):514-519,6.
