中国药理学通报2001，Vol.17Issue(1)：51-54,4.
合成鱼腥草素对脾切除动物细胞免疫功能的影响
The effect of Houttuyninum on cellar immunoiogic
function in splenectomy animals
邵兰 1于庆海 2黄晴 1刘树森1
作者信息
- 1. 中国科学院动物研究所
- 2. 沈阳药科大学药理教研室,
- 折叠
摘要
Abstract
AIM To investigated the effect and mechanism of Houttuynium (HOU) on splenectomy animals. METHODS The models of splenectomy mice and splenectomy rats were made and delayed type hypersensitivity (DTH) reaction, ANAE (+) cell percentage of peripheral blood lymphocytes, Con A-induced thymus and groin lymph node lymphocyte proliferation, the amount of lymphocytes of groin lymph node,and T cell subpopulation in peripheral blood were measured. RESULTS HOU ig (60 mg*kg-1, 120 mg*kg-1) can strikingly enhanced delayed type hypersensitivity (DTH) reaction, ANAE(+) cell percentage of peripheral blood lymphocytes. strengthened Con A-induced groin lymph node lymphocyte proliferation, raised the amount of lymphocytes of groin lymph node in splenectomy mice. But the effects of them on Con A-induced thymus lymphocyte proliferation were not apparent. HOU ig (40 mg*kg-1, 80 mg*kg-1) improved Th subset, reduced Ts subset, and then modulated the rate of Th/Ts in splenectomy rats. CONCLUSION HOU strengthened the cellar immune function of splenectomy animals by promoting the compensating capability of lymph node and regulating T cell subpopulation.关键词
合成鱼腥草素/脾切除/细胞免疫/T细胞增殖/淋巴结/T细胞分类
医药卫生引用本文复制引用
邵兰,于庆海,黄晴,刘树森..合成鱼腥草素对脾切除动物细胞免疫功能的影响[J].中国药理学通报,2001,17(1):51-54,4.
