第一军医大学学报2000，Vol.20Issue(6)：517-518,2.
OK-432和IL-2联合用药对C57BL/6 小鼠Lewis肺癌的抑制作用及Bcl-2表达的影响
Effect of combined treatment with OK-432 and interleukine-2 and Bcl-2 expression in Lewis lung cancer in C57BL/6 mice
周洁 1司兆学 1董红林 1梁海清 1蔡军伟 1单罢安 1杨晶1
作者信息
- 1. 第一军医大学分校病理教研室，广东 广州510315
- 折叠
摘要
Abstract
Objective To study the effect of OK-432 in combination with IL-2 on Lewis lung cancer (LLC) growth and bcl-2 expression in C57BL/6 mice. Methods Forty C57BL/6 mice bearing LLC were divided into 4 groups and injected with 0.9% NaCl solution, OK-432, IL-2 and OK-432/IL-2. The inhibition of tumor growth after the drug administration and the expression of bcl-2 in paraffin-embedded primary tumor tissues were observed with SABC. Results The growth of LLC in the group with combined treatment was significantly inhibited. ( with inhibition rate of 60%, P < 0.05). The expression of bcl-2 in this group was significantly lowered compared with control group (P < 0.05). Conclusions OK-432 and IL-2 has distinct synergetic anti-tumor effect, possibly by attacking the tumor cells directly or indirectly, and the improved interaction of cells due to inhibition of bcl-2 gene expression and induction of tumor cell apoptosis may also contribute to this effect.关键词
A组溶血性链球菌冻干生物制剂/白细胞介素-2/bcl-2/肺癌/抗瘤效应/生物治疗Key words
OK-432/IL-2/bcl-2/lung cancer/anti-tumor effect/biotherapy分类
医药卫生引用本文复制引用
周洁,司兆学,董红林,梁海清,蔡军伟,单罢安,杨晶..OK-432和IL-2联合用药对C57BL/6 小鼠Lewis肺癌的抑制作用及Bcl-2表达的影响[J].第一军医大学学报,2000,20(6):517-518,2.
