摘要
Abstract
BACKGROUND: The therapeutic effects of Chinese herbs for tonifying kidney on the prevention and treatment of post-menopausal osteoporosis have been determined, but there is few report on the action of these on the prevention against male osteoporosis.OBJECTIVE: To study the effect of Chinese herbs for tonigying kidney on the prevention against male osteoporosis.DESIGN: Randomized controlled trial.SETTING and PARTICIPANTS: A total of 44 senile males, with the symptoms of the declined bone density diagnosed by the physical check in the clinic or ward in the hospital in Wuhan city, were selected as the receptors and divided into the Chinese herb group and control group.INTERVENTIONS: The Chinese herb group and control group were divided at random in the research. In the Chinese herb group, both migupian and calcium were applied, but in the control, only calcium applied, lasting for 1year.MAIN OUTCOME MEASURES: At the beginning and the end of the research, the bone mineral density(BMD) of the lumbar vertebrae and the upper femur were measured, as well as s-BGP and Hop/Cr.RESULTS: After 12-month medicine application, BMD of the lumbar vertebrae in the Chinese herb group was slightly increased[ (0. 841 ± 0. 022 )g/cm2before the treatment, (0. 871 ±0. 019) g/cm2 after the treatment, P ＞0.05]; BMD of the femoral neck, Ward's triangular part and the femoral trochanter were significantly increased[ (0. 716 ± 0. 031), (0. 509 ±0. 014), (0. 597 ±0. 013) g/cm2 successively before the treatment;(0. 766 ±0. 027), (0. 552 ±0. 018), (0. 656 ±0. 016) g/cm2 successively after the treatment, t = 8.92, 14.93, 22. 14, P ＜ 0.05] . In the control,BMD was remarkably decreased in every part. But s-BGP and Hop/Cr in the control were increased, and no significant change in the Chinese herb group.CONCLUSION: Migupian can prevent bone loss in senile male by inhibiting bone transformation.关键词
补肾药/骨密度/骨钙素/老年人/骨质疏松分类
医药卫生
