动物营养学报2009，Vol.21Issue(4)：519-524,6.DOI:10.3969/j.issn.1006-267x.2009.04.016
α-酮戊二酸对脂多糖应激断奶仔猪生长抑制的缓解作用
Attenuating Effects of α-ketoglutaric Acid on Growth Depression in Weaned Pigs Challenged with Lipopolysaccharide
摘要
Abstract
Constituting a stress model by repeatedly challenged with lipopolysaccharide (LPS) in weaned pigs, the experiment that was researched on effects of α-ketoglutaric acid (AKG) on growth performance and plasma hormones level was aimed at whether AKG could alleviate the reaction to stress in weaned pigs.Twenty-four healthy crossbred Duroc× Landrace × Largewhite weaned piglets with body weight of (7.25±0.23) kg were randomly allocated to 3 groups (control group, LPS control group and AKG group).Every group included 8 replicates and 1 piglet in per replicate.The control group and LPS control group were fed the basal ration adding with 1% amylum, while AKG group was fed the basal ration adding with 1% AKG.Piglets in LPS control and AKG group were injected intraperitoneally with 80 μg/kg LPS every other day (on day 10, 12, 14 and 16 of experiment).The results showed that: 1) from day 1 to day 9 (without LPS challenge), ADG in AKG group increased by 30.0% (P<0.05) and 31.1% (P<0.05) compared with control group and LPS control group, respec-tively; meanwhile, F/G decreased by 12.4% (P<0.05) and 12.8% (P<0.05); from day 10 to day 16 (with LPS chal-lenge), ADG and F/G in LPS control group decreased by 28.8% (P<0.05) and increased by 16.8% (P<0.05) compared with control group, respectively; while, there was no significant difference between AKG group and control group on ADG and F/G (P>0.05) ; 2) in comparison with control group, insulin-like growth factor-Ⅰ(IGF-Ⅰ) of plasma in LPS control group decreased by 22.7% (P<0.05) after LPS challenged firstly (on day 10 of experiment), but no significant difference was found in AKG group and control group; after repeated challenge with LPS (on day 16 of experiment), IGF-Ⅰ and insu-lin of plasma in LPS group decreased by 21.2% (P<0.05)and 25.7% (P<0.05) ; meanwhile, these indexes had no signifi-cant difference between AKG group and control group (P>0.05).The results indicated that dietary supplementation with 1% AKG could significantly relieve the growth depression of weaned piglets challenged by LPS.关键词
α-酮戊二酸/脂多糖/断奶仔猪/生长性能/血浆激素水平Key words
α-ketoglutarate acid/Lipopolysaccharide/Weaned pigs/Growth performance/Plasma hormones level分类
农业科技引用本文复制引用
刘坚,侯永清,丁斌鹰,刘玉兰,朱惠玲,王蕾,李永塘..α-酮戊二酸对脂多糖应激断奶仔猪生长抑制的缓解作用[J].动物营养学报,2009,21(4):519-524,6.基金项目
国家自然科学基金项目(30871801) （30871801）
湖北省自然科学基金计划创新群体项目(2007ABC009) （2007ABC009）
