眼科学报2005，Vol.21Issue(1)：52-55,4.
Distribution of the Toxin following Medial Rectus Muscular Injection of Botulinum Toxin Gel in Rabbits
Distribution of the Toxin following Medial Rectus Muscular Injection of Botulinum Toxin Gel in Rabbits
Jingchang Chen 1Guanghuan Mai 1Xinping Yu 1Huanyuan Yu 1Heping Wu 1Xiaoming Lin 1Daming Deng 1Ying Kang1
作者信息
- 1. Zhongshan Ophthalmic Center, Sun Yat-sen Universtity, Guangzhou 510060, China
- 折叠
摘要
Abstract
Purpose: To determine the distribution of the toxin among individual muscles after intramuscular injection of botulinum toxin gel.Methods: One eye of 7 New Zealand white rabbits was randomized into group A, and the contralateral eye was into group B. Eyes in group A received medial rectus intramuscular injection of 2.5 IU of 125I-BTX-A gel in 0.1 ml, and those in group B received equivalent amount of 125I-BTX-A solution by medial rectus intramuscular injection. Four rectus muscles and the levator palpebrae superioris were harvested and the radioactivity of muscles was measured 16 hours after the injection.Results: In group A, the radioactivity of per gram medial rectus was significantly higher than that of other muscles (P ＜ 0.01), and there was no statistically significant difference in the radioactivity of per gram muscles among other muscles (P ＞ 0.05). In group B, the radioactivity of per gram medial rectus and levator palpebrae superioris was significantly higher than that of other muscles respectively(P ＜ 0.05), and the difference in the radioactivity of per gram muscles between medial rectus and levator palpebrae superioris was not statistically significant (P ＞ 0.05). The radioactivity of per gram medial rectus in group A was higher than that in group B (t=3.731 ,P=0.01), and there was no significant difference in the radioactivity of per gram muscles among other homonymous muscles (P ＞ 0.05).Conclusion: The toxin dispersed principally in the injected muscle and the local concentration of the toxin was much high following intramuscular injection of botulinum toxin gel.关键词
botulinum toxin/strabismus/complication/hyaluronate/gelKey words
botulinum toxin/strabismus/complication/hyaluronate/gel引用本文复制引用
Jingchang Chen,Guanghuan Mai,Xinping Yu,Huanyuan Yu,Heping Wu,Xiaoming Lin,Daming Deng,Ying Kang..Distribution of the Toxin following Medial Rectus Muscular Injection of Botulinum Toxin Gel in Rabbits[J].眼科学报,2005,21(1):52-55,4.
