中华医学杂志（英文版）2008，Vol.121Issue(6)：534-539,6.
Comparison of coronary plaque composition among patients with acute coronary syndrome and stable coronary artery disease
Comparison of coronary plaque composition among patients with acute coronary syndrome and stable coronary artery disease
LI Xin-ming 1HUANG Cong-xin 1WANG Tian-song 2ZHUANG Shao-wei 2ZHOU Hua 2TIAN Bei2
作者信息
- 1. Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan,Hubei 320089,China
- 2. Department of Cardiology,Shanghai East Hospital Affiliated to Tongii University,Shanghai 200120,China
- 折叠
摘要
Abstract
Background The identification of vulnerable plaques before rupture is an important clinical goal.The purpose of the present study was to assess the difference in plaque composition among patients with acute coronary syndrome(ACS) and stable coronary artery disease(SCAD)by intravascular ultrasound virtual histologic analysis.Methods One hundred and thirty-nine patients were divided into ACS group and SCAD group according to clinical presentation.A total of 229 de novo lesions with＞50% stenosis in native coronary arteries with diameters ＞2.5 mm were studied with intravascular ultrasonography.Geometric and compositional data were obtained using intravascular ultrasound virtual histology software.Results There were no significant differences in overall lesions for fibrous((52.0±11.9)%vs(54.3±8.5)%,P＞0.05),fibrolipidic((12.3±10.1)%vs(13.8±9.5)%,P＞O.05),calcium((14.0±9.1)%vs(19.3±13.1)%,P＞0.05),or necrotic core ((22±0±11.1)%vs(19.7±5.4)%,P＞0.05)percentages in ACS and SCAD patients,respectively.There were also no significant differences in culprit lesions for fibrous((46.4±12.0)%vs(53.6±8.8)%,P＞0.05),fibrolipidic((9.1±9.0)% vs (12.9±9.7)%,P＞0.05),calcium((16.6±9.7)%vs(21.8±26.3)%,P＞0.05),or necrotic core((28.0±12.6)%vs(20.6±5.2)%,P＞0.05)percentages in ACS and SCAD patients,respectively.High density lipoprotein-cholesterol levels＞1.04 mmol/L were associated with more fibrolipidic((14.5±10.4)%vs(7.1±6.5)%,P＜0.05)and less necrotic core((20.6±9.7)%vs (27.9±12.6)%,P＜0.05)percentages in the cohort with ACS.Conclusions In this study,coronary plaque composition assessed by intravascular ultrasound virtual histologic analysis was not significantly different between ACS and SCAD patients.The anatomic relationship of the specific plaque components to the lumen of the vessel was more important than the quantitative information of plaque composition for plaque stability.关键词
coronary plaque composition/acute coronary syndrome/coronary artery disease/ultrasonography,interventional/arteriosclerosisKey words
coronary plaque composition/acute coronary syndrome/coronary artery disease/ultrasonography,interventional/arteriosclerosis分类
医药卫生引用本文复制引用
LI Xin-ming,HUANG Cong-xin,WANG Tian-song,ZHUANG Shao-wei,ZHOU Hua,TIAN Bei..Comparison of coronary plaque composition among patients with acute coronary syndrome and stable coronary artery disease[J].中华医学杂志（英文版）,2008,121(6):534-539,6.
