中德临床肿瘤学杂志（英文版）2007，Vol.6Issue(6)：537-541,5.
复方藤梨根制剂对PG荷瘤裸鼠Cx43基因表达水平及E-钙粘附素影响的研究
The effects of FuFangTengLiGen preparation regulating the expressions of Cx43 and E-cad of transplantation tumor of PG cell
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作者信息
- 1. Department of Oncology, The First Affiliated Hospital of Zhejiang T.C.M. University, Hangzhou 310006, China;Department of Oncology, The First Affiliated Hospital of Zhejiang T.C.M. University, Hangzhou 310006, China;Department of Oncology, The First Affiliated Hospital of Zhejiang T.C.M. University, Hangzhou 310006, China;Department of Oncology, The First Affiliated Hospital of Zhejiang T.C.M. University, Hangzhou 310006, China
- 折叠
摘要
Abstract
Objective: To study the anticancer effect of Chinese compound recipe FuFangTengLiGen (FFTLG) against transplantation tumor of PG cell and preliminarily explore the connection with connexin43 (Cx43) and epithelial cadherin (E-cad).Methods: Model rats of transplantation tumor of human large cell cancer PG were established. The low, medium and high dose groups of FFTLG, the blank control group were set up. After 21 days medication of FFTLG through gastrogavage, the antitumor effect of each group was compared. The gene expressions of Cx43 and E-cad in each group were quantitatively detected and compared by the application of immunohistochemistry technique. Results: FFTLG could significantly inhibit the growth of transplantation tumor. FFTLG could obviously up-regulate the expressions of Cx43 and E-cad, which in the low/medium and high dose groups were separately higher than that in the blank group. Conclusion: FFTLG has definite antitumor effect against human large cell cancer and can obviously up-regulate the expressions of Cx43 and E-cad, which may be correlated with its effect of anti-tumor.关键词
FuFangTengLiGen (FFTLG)/ lung cancer cell/ anticancer/ connexin43 (Cx43)/ epithelial cadherin (E-cad)Key words
FuFangTengLiGen (FFTLG)/ lung cancer cell/ anticancer/ connexin43 (Cx43)/ epithelial cadherin (E-cad)分类
临床医学引用本文复制引用
..复方藤梨根制剂对PG荷瘤裸鼠Cx43基因表达水平及E-钙粘附素影响的研究[J].中德临床肿瘤学杂志（英文版）,2007,6(6):537-541,5.
