中德临床肿瘤学杂志（英文版）2008，Vol.7Issue(9)：538-541,4.
乳腺癌干细胞多药耐药基因的表达及意义
The expression and significance of multi-drug resistance genes in breast cancer stem cells
摘要
Abstract
Objective:To approach the expressions of MDR1 and BCRP in breast cancer stem cells and differentiated cells.Methods:The breast cancer stem calls were separated from human breast cancer primary tissues and MCF-7 by flow cytometry.Then we measured the expressions of MDR1 and BCRP with different subset cells by Realtime-PCR.Results:Contrasted with breast cancer differentiated cells,the expressions of MDR1 and BCRP in breast cancer stem calls were higher (P＜0.01),and the proportion of stem cells rose after chemotherapy (P＜0.01).Conclusion:Contrasted with breast cancer differentiated cells,breast cancer stem cells have stronger ability of clrug-resistanca with higher level of multi-drug resistance genes,and it is one of key points for chemotherapy failure of breast cancer.关键词
stem cell/breast cancer/chemotherapy/multi-drug resistanceKey words
stem cell/breast cancer/chemotherapy/multi-drug resistance分类
医药卫生引用本文复制引用
Zhi Li,Chunping Liu,Yanli He,Jinghui Zhang,Tao Huang..乳腺癌干细胞多药耐药基因的表达及意义[J].中德临床肿瘤学杂志（英文版）,2008,7(9):538-541,4.基金项目
Supported by grants from National Natural Science Foundation Project (No.30571798) and the Major Scientific and Technological Research Project of 11th Five-Year Plan of Hubei Province (No.2006AA301A05). （No.30571798）
