现代康复2001，Vol.5Issue(5)：54-55,2.
磁共振质子波谱无创性分析活体情况下阿尔茨海默
病人脑组织生化代谢改变
Study on biochemical metabolism of brain tissues by proton magnetic resonance spectroscopy in Alzheimer patients
张桂青 1谢敬霞 2杜湘珂 3王宏 1王华丽4
作者信息
- 1. 武装警察部队总医院,
- 2. 北京大学人民医院
- 3. 北京大学 第三医院
- 4. 北京大学精神卫生研究所
- 折叠
摘要
Abstract
objective To study the metabolic alterations in medial temporal lobe of Alzheimer disease (AD) patients with proton magnetic
resonance spectroscopy and provide base for clinical diagnosis. Method Proton magnetic resonance spectroscopy were performed in the media]temporal lobe in 15 AD patients and 15 healthy control using STEAM sequence. We also studied the correlation between the ratio of NAA/Cr,mI/Cr and MMSE, and the volume of hippocampal strucfture. Result Decreased ratio of NAA/Cr was positively related to MMSE score and
volume of hippocampal sructure , the increased ratio of mI/Cr was negatively related to MMSE and volume of hippocampal stmc-ture. Conclusion 1H-MRS could provide metabolic information of brain tissue noninvasively in AD patients in vivo. The combination of highmI and low NAA could improved diagnosis of AD.关键词
1H-MRS所显示的AD的NAA降低和mI升高能提高中早期AD的诊断正确率。分类
医药卫生引用本文复制引用
张桂青,谢敬霞,杜湘珂,王宏,王华丽..磁共振质子波谱无创性分析活体情况下阿尔茨海默
病人脑组织生化代谢改变[J].现代康复,2001,5(5):54-55,2.
