兰州大学学报（医学版）2009，Vol.35Issue(2)：54-57,4.
紫杉醇+顺铂同步放、化治疗局部中晚期宫颈癌的临床观察
Clinical efficacy of concurrent chemoradiotherapy using paclitaxel and cisplatin in the treatment of advanced cervical cancer
任锦霞 1王小虎 1赵林 1吉宏 1欧阳水根1
作者信息
- 1. 甘肃省肿瘤医院,放疗科,甘肃,兰州,730050
- 折叠
摘要
Abstract
Objective To investigate the clinical efficacy of concurrent chemoradiotherapy using paclitaxel and cisplatin in the treatment of advanced cervical cancer. Methods 70 patients with local advanced cervical cancer at stages Ⅱb-Ⅳa were randomly divided into 2 groups with 36 patients received radiotherapy alone and the others received concurrent chemoradiotherapy. The same radiotherapy was performed to all patients. External beam radiation was delivered with a fraction dose of 2 Gy per day for 5 days a week during a 5-week period and fraction size of intracavitary brachytherapy is 6～7 Gy to point A. Pacilitaxel at 135 mg/m2 was administered in the first day and cisplatin at 30 mg was administered from the first to the fourth day. The total was 2 cycles with 28 days per cycle. Results The efficacy of concurrent chemoradiotherapy was significantly higher than that of radiotherapy alone (P<0.05) and the side effects in concurrent chemoradiotherapy group were significantly higher than those in radiotherapy alone (P<0.05), including bone marrow suppression,nausea,vomiting,diarrhea and other gastrointestinal reac- tions. There were no significant differences in radiated rectisis rate and radiated cystisis rate between concurrent chemoradiotherapy and radiotherapy alone (P<0.05). Conclusion Concur- rent chemoradiotherapy using paclitaxel and cisplatin might improve short-term efficacy of local advanced cervical cancer within tolerable toxicity.关键词
宫颈癌/紫杉醇/放射治疗/化学治疗Key words
cervical cancer/paclitaxel/radiation therapy/chemotherapy分类
医药卫生引用本文复制引用
任锦霞,王小虎,赵林,吉宏,欧阳水根..紫杉醇+顺铂同步放、化治疗局部中晚期宫颈癌的临床观察[J].兰州大学学报（医学版）,2009,35(2):54-57,4.
