肿瘤防治研究2009，Vol.36Issue(7)：549-551,3.DOI:10.3971/j.issn.1000-8578.2009.07.003
槲皮素对人乳腺癌细胞MDA-MB-435S增殖及侵袭力的影响
Effect of Quercatin on Proliferation and Invasion of Human Breast Carcinoma Cell Line MDA-MB-435S
李昆 1李世正 2张蕴莉 1张俊华 2李锦成 2单吉贤3
作者信息
- 1. 121001,辽宁锦州,辽宁医学院附属第一医院检验科
- 2. 121001,辽宁锦州,辽宁医学院附属第一医院普外科
- 3. 中国医科大学附属第一医院肿瘤外科
- 折叠
摘要
Abstract
Objective To investigate the effect of quercetin on the proliferation and invasion in human breast cancer cells. Methods The proliferate capacity of human breast carcinoma cell line MDA-MB-435 S was measured using tryan blue dye exclusion test, the apoptosis rate was analyzed using flow eytometry and the invasive capacity was measured using Boyden chamber invasive model after the cells were treated with different concentrations of quercetin (12. 5,25,50,100 and 200 μM) . Results Quereatin could in-hibit the proliferation and invasion and induce apoptosis of MDA-MB-435S cells at dose dependent rela-tionships. With 200 μM of quereatin the growth and invasion of MDA-MB-435S cells were almost com-pletely inhibited. Conelasion Quercatin could inhabit the proliferation and invasion and induce apoptosis of human breast carcinoma cell line MDA-MB-435S at dose dependent patterns, which could provide some bases for the clinical application of quercatin for breast cancer therapy in the near future.关键词
槲皮素/乳腺癌/增殖/侵袭力Key words
Quercetin/Breast carcinoma/Proliferation/Invasion分类
医药卫生引用本文复制引用
李昆,李世正,张蕴莉,张俊华,李锦成,单吉贤..槲皮素对人乳腺癌细胞MDA-MB-435S增殖及侵袭力的影响[J].肿瘤防治研究,2009,36(7):549-551,3.
