中华医学杂志（英文版）2002，Vol.115Issue(4)：555-558,4.
血管内栓塞材料甲基丙烯酸共聚物的实验研究
Experimental study of Eudragit mixture as a new nonadhesive liquid embolic material
石忠松 1黄正松 1张跃卫 1齐铁伟 1初明 1包大士1
作者信息
- 1. 中山大学附属第一医院神经外科,广州,510080
- 折叠
摘要
Abstract
Objective To assess the embolic effects and biocompatibility of Eudragit mixture, a new liquid embolic agent.Methods In vitro, the viscosity and precipitation time of Eudragit mixtures at several concentrations were measured to study the best proportion of components of the mixture. In vivo, a branch of the right external carotid artery was embolized with Eudragit mixture in 12 rabbits, and with n-butyl cyanoacrylate in another 12 rabbits for a comparative study of the general, angiographic and histopathologic changes between the two groups.Results Eudragit mixture containing 7.5g Eudragit, 50ml absolute ethanol and 50ml iopromide was shown in vitro to have good properties including rapid precipitation and soft elastic sponge formation upon contact with blood; in vivo, to be nontoxic, nonadherent to the microcatheter and able to embolize the vascular lumen completely without later recanalisation.Conclusion Eudragit mixture is an effective, nontoxic, safe and promising liquid embolic agent.关键词
脑动静脉畸形/血管内治疗/栓塞材料Key words
cerebral arteriovenous malformation/endovascluar treatment/embolic agent分类
医药卫生引用本文复制引用
石忠松,黄正松,张跃卫,齐铁伟,初明,包大士..血管内栓塞材料甲基丙烯酸共聚物的实验研究[J].中华医学杂志（英文版）,2002,115(4):555-558,4.
