中国现代医学杂志2003，Vol.13Issue(19)：55-57,3.
乌司他丁预防小鼠术后腹腔粘连实验研究
PREVENTION OF POSTOPERATIVE PERITONEAL ADHESIONS BY ULIANSTATIN IN MICE
杨雁灵 1徐小平 2李开宗 1窦科峰 1岳树强1
作者信息
- 1. 第四军医大学西京医院肝胆外科,西安,710032
- 2. 第一军医大学珠江医院普通外科,广州,510282
- 折叠
摘要
Abstract
Objective:To assess the ability of ulinastatin to prevent postoperative peritoneal adhesions formation in mice.Methods:60 BALB/c mice were randomly divided into two groups: ulinastatin group (n=30) and control group (n=30).After an identical peritoneal injury operation, mice were treated intraperitioneally with ulinastatin or saline at the time of abdominal closure. The mice were killed 20 days after operation, then the abdominal incisions and the development of intraabdominal adhesions were observed. Adhesion scoring was based on an overall assessment of the extent, location and adhesions type.Results:Ulinastatin group had significantly lower adhesion scores (1.28±0.31) than the control group (2.33±0.47). When two groups were analyzed for the presence of grade 2～3 adhesions (advanced significant adhesions), the ulinastatin group had significantly lower incidence (23.3%) than control group (76.7%). No incisional hernia was found in abdominal wall in all cases.Conclusions:The intraperitoneal administration of ulinastatin could inhibit postoperative adhesion formation, and has no obviously side-effect on incision healing.关键词
乌司他丁/腹膜粘连/疾病模型Key words
Ulinastatin/Peritoneal Adhesion/Disease Models分类
医药卫生引用本文复制引用
杨雁灵,徐小平,李开宗,窦科峰,岳树强..乌司他丁预防小鼠术后腹腔粘连实验研究[J].中国现代医学杂志,2003,13(19):55-57,3.
