中国组织工程研究与临床康复2009，Vol.13Issue(28)：5575-5579,5.DOI:10.3969/j.issn.1673-8225.2009.28.037
强直性脊柱炎患者股骨密度与腰椎椎体骨折的相关性
Association of femoral bone mineral density with lumbar vertebral fractures in patients with ankylosing spondylitis
魏萌 1谢庆云 2杨晓平 1徐沪济1
作者信息
- 1. 解放军第二军医大学长征医院风湿科,上海市200003
- 2. 解放军成都军区总医院骨科,四川省成都市,610083
- 折叠
摘要
Abstract
OBJECTIVE: Previous opinions consider the secondary diffuse osteoporosis as the very cause of vertebral fractures in patients with ankylosing spondylitis (AS). However, recent studies on bone mineral density (BMD) and vertebral fractures in AS patients reveal that there is no relation between the two. This article aims at investigating the association of lumbar vertebral fractures with clinical, laboratory, and imaging indexes in AS patients.METHODS: A contrast observation was performed between 65 AS patients and 62 healthy physical examinees, whose lumbar vertebral plain radiographs were taken for checking vertebral fractures. Disease activity evaluation indexes included C-reactive protein, erythrocyte sedimentation rate, finger-to-ground distance, Schobar's index score, Bath AS radiology index (BASRI) and syndesmophyte score. Dual energy X-ray absorptiometry technique was used to measure BMD levels of lumbar vertebras and femurs.RESULTS: Out of the total 65 AS patients, 10 ones (15.4%) had lumbar vertebral fractures, with 4 ones with wedge deformities and the other 6 ones with biconcave deformities. BMD levels of Lumbar vertebras and femurs in AS patients were significantly lower than those in controls (P < 0.01). There were significant differences in Schober's index scores, finger-to-ground distance scores, Bath scores, syndesmophyta scores and intertrochanter BMD values between AS patients with and without vertebral fractures (P < 0.01 ). Multiple logistic regression analyses revealed that intertrochanter BMD values were independently associated with lumbar vertebral fractures in AS patients (P =0.043).CONCLUSION: There is a correlation between low femoral BMD levels and the risk of lumbar vertebral fractures in patients with AS, especially at the intertrochanter area.关键词
强直性脊柱炎/骨质疏松/股骨/骨密度/椎体骨折分类
医药卫生引用本文复制引用
魏萌,谢庆云,杨晓平,徐沪济..强直性脊柱炎患者股骨密度与腰椎椎体骨折的相关性[J].中国组织工程研究与临床康复,2009,13(28):5575-5579,5.
