西安医科大学学报2000，Vol.21Issue(6)：560-562,3.
Bcl-2蛋白与P-糖蛋白在胃癌中的表达及其相关性研究
Study on the relationship between expressions of Bcl-2 protein and P-glycoprotein in gastric carcinoma
谢国明 1李旭 2陈葳 1程小丽 1付伟1
作者信息
- 1. 西安交通大学第一医院临床分子生物中心，西安 710061
- 2. 河南省焦作市人民医院肿瘤内科，焦作 454002
- 折叠
摘要
Abstract
Objective To evaluate the effects of Bcl-2 protein and P-glycoprotein(P-gp) in gastric carcinogenesis,tumor progression and drug resistant occurrence of gastric carcinoma. The relationship between Bcl-2 protein and P-gp was explored. Methods The expressions of Bcl-2 protein and P-gp were examined with SP immunohistochemical technique in 70 cases of gastric carcinoma. Results Bcl-2 protein expression rates were as the followings:35.7 % (25/70) in gastric carcinoma and 5% (1/20) in normal gastric mucosa. P-gp positive rates in tissues mentioned above were 30. 0 % (21/70) and 15 % (3/20), respectively. Bcl-2 positive rate in well differentiated adenocarcinomas were significantly higher than those undifferentiated carcinomas(P < 0.05). Bcl-2 positive rate in carcinomas whose histological grade was I were significantly higher than those in grade m (P < 0.05). In patients with lymphonode metastases, P-gp positive rate were significantly higher than those in patients without lymphonode metastases(P < 0.05). The P-gp positive rates in the caranomas with serious coat involvement were significantly higher than those in carcinomas without serious coat involvement(P <0.05). The co-expression rate of bcl-2 protein and P-gp in gastric carcinomawere 21.4% (15/70)(P<0.05). Conclusion Bcl-2 protein play a role in gastric carcinogenesis. P gp expression indicates there is primary drug resistance in gastric carcinoma and it is belived to becorrelated with poor prognosis. It may has the effect to motivate the diffussional transference andmetastasis of gastric carcinoma. There was significant relation between Bcl-2 protein and P-gp expression关键词
胃肿瘤/Bcl-2蛋白/P-糖蛋白/多药耐药Key words
stomach neoplasms/Bcl-2 protein/P-glycoprotein/multidrug resistant分类
医药卫生引用本文复制引用
谢国明,李旭,陈葳,程小丽,付伟..Bcl-2蛋白与P-糖蛋白在胃癌中的表达及其相关性研究[J].西安医科大学学报,2000,21(6):560-562,3.
