中德临床肿瘤学杂志(英文版)2008，Vol.7Issue(10)：560-563,4.
艾迪注射液对晚期非小细胞肺癌NP方案化疗的影响
Effects of Aidi injection on vinorelbine plus cisplatin chemotherapy for advanced non-small cell lung cancer
Ximing Xu 1Wei Ge 1Guangjin Yuan2
作者信息
- 1. Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
- 2. Department of Oncology, The First People's Hospital of Jingzhou, Jingzhou 434000, China
- 折叠
摘要
Abstract
Objective: To evaluate the effects of Aidi injection on vinorelbine plus cisplatin (NP) chemotherapy for advanced non-small cell lung cancer (NSCLC). Methods: Ninety eight patients with advanced NSCLC were randomized to receive either NP alone or NP plus Aidi injection every 3 weeks. The primary endpoint was overall survival; secondary endpoints included overall response rate, time to progression, and safety. Results: The median overall survival time was 11.6 months in NP plus Aidi-treated patients and 10.1 months in NP alone-treated ones, and 1- and 2-year survival rates were higher in the former (47% and 22%) than the latter (42% and 15%). The overall response rates in Aidi injection plus NP-treated patients tended to be higher but not statistically significant compared with NP alone-treated ones. The occurrence rates of grades 3 or 4 toxicities, e.g. fatigue, nausea, vomiting, appetite loss, leucopenia, thrombocytopenia and anemia, were lower in Aidi injection plus NP-treated patients than NP alone-treated ones, although not significantly different between them. Conclusion: Aidi injection promotes NP chemotherapeutic effects, reduces the toxicities, and improves the patients' tolerance to chemotherapy as well. It may be an effective adjunct to chemotherapy in patients with NSCLC.关键词
non-small cell lung cancer (NSCLC)/Aidi injection/chemotherapyKey words
non-small cell lung cancer (NSCLC)/Aidi injection/chemotherapy分类
医药卫生引用本文复制引用
Ximing Xu,Wei Ge,Guangjin Yuan..艾迪注射液对晚期非小细胞肺癌NP方案化疗的影响[J].中德临床肿瘤学杂志(英文版),2008,7(10):560-563,4.
