中华医学杂志（英文版）2003，Vol.116Issue(4)：565-568,4.
The effect of lead on brainstem auditory evoked potentials in children
The effect of lead on brainstem auditory evoked potentials in children
邹朝春 1赵正言 1唐兰芳 1陈志敏 1杜立中1
作者信息
- 1. Department of Medicine, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
- 折叠
摘要
Abstract
Objective To determine whether lead affects brainstem auditory evoked potentials (BAEPs) in low-to-moderate lead exposed children. Methods BAEPs were recorded from 114 asymptomatic children aged 1-6 years. Average values were calculated for peak latency (PL) and amplitude (Amp). Whole blood lead (PbB) levels were assessed by graphite furnace atomic absorption spectroscopy. Based on their PbB levels, subjects were divided into low lead (PbB<100 μg/L) and high lead subgroups (PbB ≥100 μg/L). Results The PbB levels of the 114 subjects ranged from 32.0 to 380.0 μg/L in a positively skewed distribution. The median of PbB levels was 90.0 μg/L while the arithmetic average was 88.0 μg/L. Of the subjects, 43.0% (49/114) had levels equal to or greater than 100 μg/L. Bilateral PLs Ⅰ, Ⅴ, and Ⅲ of the left ear in the high lead subgroup were significantly longer than those in the low lead subgroup (P<0.05). A positive correlation was found between PbB levels and bilateral PLs Ⅰ, Ⅴ and Ⅲ of the left ear (P<0.05), after controlling for age and gender as confounding factors. A significant and positive correlation between PbB levels and PL Ⅰ of the left ear, even when PbB levels were lower than 100 μg/L, in the low subgroup (r=0.295, P=0.019) was also found.Conclusions Lead poisoning in children younger than 6 years old is a very serious problem to which close attention should be paid. The indications that lead prolongs partial PLs may imply that lead, even at PbB levels lower than 100 μg/L, impairs both the peripheral and the central portions of the auditory system. BAEPs may be a sensitive detector of subclinical lead exposure effects on the nervous system in children.关键词
evoked potentials, auditory, brainstem/lead/childrenKey words
evoked potentials, auditory, brainstem/lead/children分类
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邹朝春,赵正言,唐兰芳,陈志敏,杜立中..The effect of lead on brainstem auditory evoked potentials in children[J].中华医学杂志（英文版）,2003,116(4):565-568,4.
