中国临床药理学与治疗学2001，Vol.6Issue(1)：56-58,3.
氯沙坦对充血性心衰患者心功能及循环NO/ET的影响
Effect of losartan on cardiac function and secretion of nitric oxide and endothelin in patients with congestive failure
王邦宁 1张传焕 1沈玉芳 1刘敏 1陈大年 1高丹屏1
作者信息
- 1. 安徽医科大学第一附属医院CCU，合肥 230022
- 折叠
摘要
Abstract
Aim To evalute the effects of losartan on the cardiac function and secretion of nitric oxide(NO) and endothelin(ET) in patients with congestive heart failure(CHF) .Methods Sixty patients with class Ⅱ～Ⅳ CHF were randomised to receive a 12 weeks of routine therapy either with losartan(n ＝ 30)to be added from 25 mg to 50 mg daily or with enalapril(n ＝ 30) to be added from 2.5 mg to 5 mg daily. The cardiac systolic and diastolic funtion and the levels of NO and ET were observed before and after therapy respectively, with 30 normal control subjects seving as control. Results The abnormal cardiac systolic and diastolic function parameter were present in patients with CHF. The ET and NO levels in CHF patients were significantly higher than those in the control group(P＜0.05) . NYHA function class was improved in 85% of losartan-treated patients and in 84% of enalapril-treated patients after 12 weeks, as compared with cardiac function at baseline. ET and NO levels were significantly reduced(P＜0.01), NO/ ET ratio was increased (P＜0.05) after 12 weeks of therapy in two active groups. Conclusion The systolic and diastolic functions of patients with CHF are greatly improved by losartan treatment, which reverses the imbalance of NO/ET and it is suspected that this action may be another important mechanism of its treating heart failure.关键词
氯沙坦充血性心力衰竭内皮素一氧化氮Key words
losartan/congestive heart failure/endothelin/nitric oxide分类
医药卫生引用本文复制引用
王邦宁,张传焕,沈玉芳,刘敏,陈大年,高丹屏..氯沙坦对充血性心衰患者心功能及循环NO/ET的影响[J].中国临床药理学与治疗学,2001,6(1):56-58,3.
