中国医科大学学报2001，Vol.30Issue(1)：56-58,3.
肾盂输尿管癌p53、nm23表达的临床意义
Clinical Significance of p53,nm23 Expression in Renel Pelvic and Ureteral Carcinoma
李军 1刘贤奎 1孔垂泽 1刘同才 1何三光 1杨涛 1袁中旗2
作者信息
- 1. 中国医科大学第一临床学院泌尿外科,
- 2. 沈阳铁路局中心医院泌尿外科
- 折叠
摘要
Abstract
Objective:Our aim was to investigate the relationship between the expression of p53,nm23 and biological progress in renal pelvic and ureteral carcinoma. Methods：The expression of p53 was detected by using immunohistochemical SABC method and the expression of nm23 was detected using in situ hybridization. Results:Positive rates of p53 and nm23 in renal pelvis and ureteral carcinoma were 51.1%(23/45),46.7%(21/45)respectively.In T2 to T3 pathological stage,p53 positive rate was 60%(21/35),while it was 20%(2/10) in T1,P<0.05.Positive rate of p53 in G1 to G2 stage was 59%(23/39),and 0%(0/6) in G1.The positive rate of nm23 was 48.6%(17/35) in T2 to T3 stage and 40%(4/10) in T1,P>0.05. In carcinoma of G2 to G3 stage,nm23 was 48.7%(19/39) positive and 33.3%(2/6) in G1,P>0.05.No significant difference was found in the incidence of multi organ urothelial carcinoma between p53,nm23 positive expression group and negative group,P>0.05. The recurrent rates of post operative bladder cancer showed no difference in group of p53 positive expression and negative expression, (P>0.05). Recurrent rate of post operative bladder cancer in nm2 positive group was 61.9%(12/21),and 20.8% in nm23 negative group,P<0.01.Survival rate in p53,nm23 positive expression group was higher than that of negative group,(P<0.01). Conclusion:Positive expression of p53 is related to pathological stage,cellular grade, and prognosis of renal pelvic and ureteral carcinoma.The expression of nm23 is related to the recurence of postoperative bladder cancer,and is helpful in predicating the recurrence of postoperative bladder cancer in renal pelvic and ureteral carcinoma.关键词
肾肿瘤/输尿管肿瘤/癌/基因,p53/nm23分类
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李军,刘贤奎,孔垂泽,刘同才,何三光,杨涛,袁中旗..肾盂输尿管癌p53、nm23表达的临床意义[J].中国医科大学学报,2001,30(1):56-58,3.
