天然产物研究与开发2006，Vol.18Issue(4)：566-568,623,4.
三七皂苷Rg1对tPA和PAI-1活性的调节作用
PAI-1 and Tpa Modulating Activity of Panax notoginsenoside Rg1
詹合琴 1杨锦南 1沈志强2
作者信息
- 1. 新乡医学院药理教研室,新乡,453003
- 2. 昆明医学院云南省天然药物药理重点实验室,昆明,650031
- 折叠
摘要
Abstract
The modulating activity of Panax notoginsenoside Rg1 on type 1 plasminogen activator inhibitor (PAI-1) and tissuetype plasminogen activator (tPA) was investigated. The activity of PAI-1 in rabbit plasma or platelet-released substances and tPA in rabbit plasma was assayed using chromogenic substrate, in vitro or in vivo. The results showed that Panax notoginsenoside Rg1, in vitro, significantly inhibited PAI-1 activity in plasma while elevating plasma tPA activity, in a concentration-dependent manner. Intravenous injection of Panax notoginsenoside Rg1 at 30 and 60 mg/kg markedly suppressed PAI-1 level in plasma as well as platelet-released substances stimulated by thrombin, while increasing plasma tPA activity. It is suggested that Panax notoginsenoside Rg1 inhibited PAI-1 activity and increased tPA activity, and this property of Panax notoginsenoside Rg1 is advantageous to its antithrombotic effect.关键词
三七皂苷Rg1/组织型纤溶酶原激活物/纤溶酶原激活物抑制物-1/家兔/血小板Key words
Panax notoginsenoside Rg1/tissue type plasminogen activator/type 1 plasminogen activator inhibitor/rabbits/platelets分类
医药卫生引用本文复制引用
詹合琴,杨锦南,沈志强..三七皂苷Rg1对tPA和PAI-1活性的调节作用[J].天然产物研究与开发,2006,18(4):566-568,623,4.
