中国临床康复2004，Vol.8Issue(3)：568-570,3.
自体骨髓干细胞原位移植对急性心肌梗死后梗死面积和心功能的影响
Effect of self-marrow stem cell transplantation in situ on the size of infarct area and cardiac functions after acute myocardium infarction
摘要
Abstract
AIM: To discuss the effects of self-marrow stem cells, which mobilized by the application of granulocyte-colony stimulating factor(G-CSF),on the size of infarct area and cardiac functions by its function of transplantation in situ at myocardium infarct sites for repairing infarct myocardium in acute myocardium infarction patients. METHODS: Twenty-five patients with acute myocardium infarction for the first time were randomly divided into stem cells transplantation in situ group transplantation group(n=12) and control group(n=13) after admissions. Transplantation group introduced G-CSF to mobilize self-marrow stem cells for progressing myocardium infarct site transplantation in situ except for routine therapy while the control group was treated by routine therapy after admissions.Routine 12-lead electrocardiogram was drawn on the first and the 28 th day after admissions.Wagner's QRS wave scoring system was introduced in cardiac function evaluation.Nuclein myocardium perfusion faultage image was taken on the 7th and the 28 th day after admissions to measure the infarction size. RESULTS: The QRS score values of transplantation group( 2.14± 0.21) obviously decreased compared with that of the control group(5.07± 0.31) after 4-week G-CSF therapy( t=5.2,P< 0.05) ;the infarction size decreased from(36± 8) % to(18± 6) % ,which was significantly smaller than that of the control group(33± 7) % (t=12.6,P< 0.05). CONCLUSION: The stem cell transplantation in situ therapy,which employs self-marrow stem cell that mobilize by G-CSF to repair necrosis myocardium tissue can decrease the infarction size and improve the cardiac function.关键词
心肌梗塞 /外科学/移植,自体/骨髓细胞/粒细胞巨噬细胞集落刺激因子分类
医药卫生引用本文复制引用
陈运贤,欧瑞明,钟雪云,徐新,赵洪云,管慧红,陆英,韩忠朝..自体骨髓干细胞原位移植对急性心肌梗死后梗死面积和心功能的影响[J].中国临床康复,2004,8(3):568-570,3.基金项目
国家攀登专项计划项目( 95 专-10) （ 95 专-10）
广东省科技厅社会发展攻关项目(2002C30604) （2002C30604）
