首页|期刊导航|中华医学杂志（英文版）|Drug-eluting stent for the treatment of small coronary lesion: comparison between sirolimus-and paclitaxel-eluting stent
Drug-eluting stent for the treatment of small coronary lesion: comparison between sirolimus-and paclitaxel-eluting stent
LI Jian-jun WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin XU Bo YANG Yue-Jin CHEN Ji-lin QIAO Shu-bin MA Wei-hua QIN Xue-wen YAO Min LIU Hai-bo
中华医学杂志（英文版）2007，Vol.120Issue(7)：569-573,5.
中华医学杂志（英文版）2007，Vol.120Issue(7)：569-573,5.
Drug-eluting stent for the treatment of small coronary lesion: comparison between sirolimus-and paclitaxel-eluting stent
Drug-eluting stent for the treatment of small coronary lesion: comparison between sirolimus-and paclitaxel-eluting stent
摘要
Abstract
Background Patients with small coronary lesions are at increased risk for repeat interventions after coronary angioplasty and stenting. The efficacy of drug-eluting stents (DES) has been demonstrated to improve the outcomes of these patients and is a focus of interest. Currently, two platforms of DES are available (sirolimus-eluting stent (SES) and paclitaxel-eluting stent (PES)). However, it has less been known that DES, SES vs PES, is superior for the treatment of small coronary lesions.Methods In this retrospective study, 87 consecutive patients with 151 lesions underwent implantation of coronary SES(n=68) and PES (n=83). Quantitative coronary angiography (QCA) was performed at the time of stent implantation and subsequently at 8 months post-stenting. Small vessel disease was defined as lesions in vessels with diameter ≤2.5 mm measured by QCA. Major adverse cardiac events (MACE) including death, thrombosis, nonfatal myocardial infarction and target lesion revascularization (TLR) were compared between the two groups.Results Baseline clinical characteristics and angiographic parameters were similar between the two groups. At clinical and angiographic follow-up, overall thrombosis rates were similar in both groups (0 vs 1.2%, P＞0.05). The TLR and in-segment restenosis were not significantly different (19.1% vs 25.3%; 10.3% vs 10.8%, P=0.365 and P=0.913respectively) between the two groups. The in-stent restenosis rate, however, was significantly higher in the PES group(4.4% vs 21.7%; P=0.002). Similarly, the late loss was significantly higher in the PES group ((0.14±0.38) mm vs (0.49±0.61) mm; P＜0.001).Conclusions In this small sample-size, non-randomized study, the data indicated that implantation of SES for the treatment of patients with small coronary lesion showed more favorable results in respect of restenosis compared with PES implantation.关键词
drug-eluting stent/coronary artery disease/angiography/restenosis/small coronary lesionKey words
drug-eluting stent/coronary artery disease/angiography/restenosis/small coronary lesion分类
医药卫生引用本文复制引用
LI Jian-jun,WU Yong-jian,YUAN Jin-qing,CHEN Jue,YOU Shi-jie,DAI Jun,XIA Ran,GAO Run-lin,XU Bo,YANG Yue-Jin,CHEN Ji-lin,QIAO Shu-bin,MA Wei-hua,QIN Xue-wen,YAO Min,LIU Hai-bo..Drug-eluting stent for the treatment of small coronary lesion: comparison between sirolimus-and paclitaxel-eluting stent[J].中华医学杂志（英文版）,2007,120(7):569-573,5.基金项目
The first two authors contributed equally to this study.This article was partly supported by a grant awarded to Dr. LI Jian-jun from Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China (No. 2004190). （No. 2004190）
