中国科学院研究生院学报2008，Vol.25Issue(4)：569-575,7.
五种五味子属药用植物及东紫苏的化学成分和生物活性
Studies on the chemical constituents and bioactivities of five Schisandra medicinal species and Elsholtzia bodinieri
摘要
Abstract
The chemical constituents and bioactivities of six medicinal plants have been studied. In the study one hundred and one compounds, including twenty-six new compounds were isolated. Among these compounds, sixteen unique highly oxidized nortriterpenoids, belonging to an unprecedented new nortriterpenoid skeleton with a biosynthetically modified eight-membered ring, and unusual nortriterpenoids or bisnortriterpenoid skeletons, have been isolated from three Schisandra species. Interestingly, to date, no naturally occurring triterpenoids have been found to have such a highly modified oxidized norcycloartane skeleton.The bioactivities of compounds isolated from the genus Schisandra have been tested, including anti-HIV-1, anti-inflammatory, and cytotoxities against C8166, MT-4 and K562 cells activities. SM-10 and SM-26 were found to show promising anti-HIV-1 activity and the selectivity index were 174.08 and 25.94, respectively.关键词
五味子属/东紫苏/化学成分/抗HIV活性/生源途径Key words
Schisandra species/Elsholtzia bodinieri/chemical constituents/anti-HIV activity/biogenetic origin分类
农业科技引用本文复制引用
李蓉涛,孙汉董..五种五味子属药用植物及东紫苏的化学成分和生物活性[J].中国科学院研究生院学报,2008,25(4):569-575,7.基金项目
supported by the National Natural Science Foundation of China (20402016) （20402016）
