动物医学进展2002，Vol.23Issue(1)：57-60,4.
猴卡氏肺孢子虫肺炎的实验研究
Experimental Pneumocystis carinii Pneumonia in the Monkeys
杨月中 1杨路2
作者信息
- 1. 台州学院生化系，浙江临海317000
- 2. 华东理工大学生物工程学院，上海200237
- 折叠
摘要
Abstract
To examine the susceptibility of monkeys to infection with aninoculum which contained Pneumocystis carinii cysts originally derived from a 2- month-old monkey that died in Pneumocystis pneumoni- a. Methods:9 6-month-old monkeys were randomly as- signed to experimental and control groups. Doses inocu- lated into trachea were 2. 8×105(monkeys 1-4) and 7. 0 × 105 (monkeys 5-8) P. Carinii cysts. Monkeys 1-4 were injected intramuscularly with 25 mg· kg-1 body weight cortisone acetate each day for 28 days before temperature and respiratory rate were monitored untill the monkeys died or were killed. Results: Monkeys 1-4 were dull, anorexic, weak, coughing and tachypnea. The severity of the signs generally was corresponding to the degree of pyreria at 27 to 33 days after inoculation. Monkeys 1-2 became very weak and dyspneic and died at 29, 31 days. Monkeys 5-8 developed subclinical signs. They were injected with cortisone acetate for 22 days at 30 days after inoculation and exhibited signs similar to Monkeys 1-4. Monkey 5 died at 23 days after injection with cortisone acetate. Conclusion: Cortisone acetate-treated Monkeys 1-4 were infected with the cysts by intratracheal injection and resulted in pyrexia, dull, anorexia weak, cough and tachypnea. Even though relatively large doses of P. Carinii cysts were ad- ministered, Monkeys 5-8 only showed subclinical signs. After Monkeys 5-8 were injected with cortisone ac- etate, they developed clinical signs similar to Monkeys 1-4.关键词
猴/卡氏肺孢子虫/肺炎/接种/感染/临床症状Key words
monkey/Pneumocystis carinii/pneumonia/inoculation/infection/clinical signs.猴卡氏肺孢子虫肺炎的实验研究杨月中 杨路 李治滢 曾丽 施时迪分类
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杨月中,杨路..猴卡氏肺孢子虫肺炎的实验研究[J].动物医学进展,2002,23(1):57-60,4.
