高等学校化学学报2001，Vol.22Issue(4)：584-586,3.
手性3,7-二甲基-5,6-二羟基-辛-7-烯醛中间体的合成
Synthesis of Chiral Intermediate (3S,5S,6S)-3,7-Dimethyl-5,6-dihydroxy-7-en-octanal of Didemnaketals Analogue
摘要
Abstract
A stereoselective synthesis of (3S,5S,6S)-3,7-dimethyl-5,6-dihydroxy-7-en-octanal, a key intermediate, for the synthesis of the HIV-inhibitory didemnaketals analogue, was performed via a series of reactions from the natural(+)-pulegone. In this approach, an interesting and valuable diastereo-recognizable reaction between tertiary hydroxyepoxides and PCC was found. Therefore, the mixture of compounds 8 and 9 was treated with PCC to recover 8 in 93% yield and de 98% purity.关键词
螺环缩酮/R-（+）-Pulegone/非对映选择性氧化/3,7-二甲基-5,6-二羟基-辛-7-烯醛中间体分类
化学化工引用本文复制引用
贾彦兴,吴滨,涂永强..手性3,7-二甲基-5,6-二羟基-辛-7-烯醛中间体的合成[J].高等学校化学学报,2001,22(4):584-586,3.
