广西科学2005，Vol.12Issue(1)：58-61,67,5.
血管内皮生长因子表达及微血管密度与头颈肿瘤发展和转移的关系
The Relationship between the Expression of Vascular Endothelial Growth Factor,Microvessel Density and the Progress,etastasis of Tumor in Head and Neck
摘要
Abstract
To investigate whether the expression of vascular endothelial growth factor(VEGF) and microvessel density (MVD) is related to the progression and metastasis of head and neck tumor,he VEGF expression and MVD were assessed by immunohistochemistry using rabbit anti-human VEGF antibody and rabbit anti-human factor Ⅷ-related antigen antibody. The VEGF expression and MVD in malignant tumors of head and neck were higher than those in benign tumors and non-tumor tissues in head and neck tissue (P<0.05).The VEGF expression and MVD in malignant tumor with metastasis was significantly increased as compared with those without metastasis (P<0.05).There was a close positive correlation between VEGF expression and MVD(r=0.398,<0.05).Thus,he VEGF expression is closely correlated with angiogenesis.It is revealed that the increases in VEGF expression and MVD may promote the progression and metastasis of head and neck tumor.Thus,EGF and MVD may have prognostic value in head and neck tumor.关键词
血管内皮生长因子/血管生成/头颈肿瘤/肿瘤转移Key words
vascular endothelial growth factor/ngiogenesis/ead and neck tumor/umor metastasis分类
医药卫生引用本文复制引用
黄光武,吉亚卜,李杰恩,邝国乾,砂川昌范,小杉忠诚..血管内皮生长因子表达及微血管密度与头颈肿瘤发展和转移的关系[J].广西科学,2005,12(1):58-61,67,5.基金项目
广西壮族自治区卫生厅重点课题(200215). （200215）
