肿瘤防治研究2009，Vol.36Issue(7)：589-592,4.DOI:10.3971/j.issn.1000-8578.2009.07.014
非霍奇金淋巴瘤组织坏死相关因素的探讨
Exploration of Related Factors of Necrosis in Non-Hodgkin's Lymphoma
摘要
Abstract
Objective To explore the related factors of necrosis in non-Hodgkin' s lymphoma(NHL). Methods One hudred and twenty-four cases of NHL Were divided into necrosis and non-necrosis group and classified into NK/T cell lymphoma (NK/TCL), T cell lymphoma (TCL) ,B cell lymphoma(BCL) groups. The expression of TNF-α, bcl-2, CD95 (Fas), CD95L(FasL)were detected by SP immuno-histochemistry. The presence of RNA(EBER1/2) was detec-ted by in situ hybridization. Follow-up studying were also performed in these cases. Results The expression rates of Fas, FasL, EBER1/2 in necrosis group were 81.5 % (22/27), 74.1%(20/27) ,82.5%(23/27),The expression rate of Fas, FasL, EBV in non-necrosis group were 68.1% (66/97), 59.8 % (58/97), 12.4 % (12/97), higher than those in non-necrosis group(P<0.005). Conversely, the high-expression rate of bcl-2 in the latter were higher than those in the former (P<0.005). The high-expression rates of Fas, FasL, EBV in NK/TCL and TCL were significantly higher than those in BCL. However, The high-expression rates of bcl-2 in NK/ TCL and TCL were significantly lower than those in BCL. There was a significant difference in the mean survival time between necrosis and non-necrosis groups (7.4 months and 24.2 months respectively, P<0.005). Conclusion The high-expression of Fas, FasL, bcl-2 and infection of EBV may play some roles in necrosis of NHL. Necrosis of NHL results from cooperation of several factors and suggests relation to prognosis.关键词
非霍奇金淋巴瘤/组织坏死/预后/Fas/FasL/EBER1/2Key words
Non-Hodgkin's lymphoma/Necrosis/Prognosis分类
医药卫生引用本文复制引用
郭瑞珍,唐文台..非霍奇金淋巴瘤组织坏死相关因素的探讨[J].肿瘤防治研究,2009,36(7):589-592,4.基金项目
贵州省教委资助项目(1999-477) （1999-477）
贵州省优秀医学青年人才基金资助项目(2002-D-188) （2002-D-188）
