|国家科技期刊平台
| 注册
首页|期刊导航|地质学报（英文版）|An In Vitro Investigation of Pulmonary Alveolar Macrophage Cytotoxicity Introduced by Fibrous and Grainy Mineral Dusts

An In Vitro Investigation of Pulmonary Alveolar Macrophage Cytotoxicity Introduced by Fibrous and Grainy Mineral Dusts

DONG Faqin DENG Jianjun WU Fengchun PU Xiaoyong John HUANG FENG Qiming HE Xiaochun

地质学报（英文版）2006，Vol.80Issue(4)：589-596,8.
✕
地质学报（英文版）2006，Vol.80Issue(4)：589-596,8.

An In Vitro Investigation of Pulmonary Alveolar Macrophage Cytotoxicity Introduced by Fibrous and Grainy Mineral Dusts

An In Vitro Investigation of Pulmonary Alveolar Macrophage Cytotoxicity Introduced by Fibrous and Grainy Mineral Dusts

DONG Faqin 1DENG Jianjun 2WU Fengchun 2PU Xiaoyong 3John HUANG 4FENG Qiming 1HE Xiaochun1

作者信息

  • 1. Institute of Mineral Materials and Application, Southwest University of Science and Technology, Mianyang, Sichuan 621002, China
  • 2. Clinical Laboratory, Fourth People's Hospital ofMianyang, Mianyang, Sichuan 621000, China
  • 3. Department of Clinical Laboratory, Third Military Medical University, Chongqing 400038, China
  • 4. Central Analytical Facility, Laurentian University, Sudbury, Ontario P3E 2C6, Canada
  • 折叠

摘要

Abstract

In order to study the damage mechanism of mineral dusts on the pulmonary alveolar macrophage (AM), the changes in their death ratio, malandialdthyde (MDA) content and activities of lactate dehydrogenase (LDH) and superoxide dismutase (SOD) were measured, and the technique of cell culture in vitro was used to investigate the cytotoxicity of six mineral dusts (twelve crystal habits)from twelve mineral deposits. The results show that wollastonite and clinoptilolite have no AM cytotoxicity, while other fibrous and grainy mineral dusts damage pulmonary AM in various degrees.The cytotoxicity of fibrous mineral dusts was greater than that of the grainy ones, and the cytotoxicity of dusts was positively correlated with the active OH- content in dusts, but not necessarily so with its SiO2 content. The high pH values produced by dust was unfavorable for the survival of cells and the dusts with low bio-resistance were safe for cells. The content of variable valence elements in dusts might influence their cytotoxicity and the surface charge of dusts was not a stable factor for their toxicity. It is demonstrated that the shape of mineral dusts was one of the factors affecting cytotoxicity, and that the cytotoxicity of mineral dusts depends mainly on their properties.

关键词

grainy mineral/fibrous mineral/dust/pulmonary alveolar macrophage/cytotoxicity

Key words

grainy mineral/fibrous mineral/dust/pulmonary alveolar macrophage/cytotoxicity

分类

天文与地球科学

引用本文复制引用

DONG Faqin,DENG Jianjun,WU Fengchun,PU Xiaoyong,John HUANG,FENG Qiming,HE Xiaochun..An In Vitro Investigation of Pulmonary Alveolar Macrophage Cytotoxicity Introduced by Fibrous and Grainy Mineral Dusts[J].地质学报（英文版）,2006,80(4):589-596,8.

基金项目

This work was supported by the National Natural Science Foundation of China (No: 40072020), the Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions of the Ministry of Education, and the Support Item of Preeminence Youth Fund, Sichuan. （No: 40072020）

地质学报（英文版）

1000-9515

访问量4
|
下载量0
段落导航相关论文