中德临床肿瘤学杂志(英文版)2008，Vol.7Issue(10)：593-596,4.
血管内皮生长因子、微血管密度在子宫平滑肌瘤中的表达意义
The effects of vascular endothelial growth factor and microvessel density in the fibromyoma uteri
Huaqing Wen 1Jihong Deng 2Ping Pu 3Haitao Wang 1Wei Yin1
作者信息
- 1. Department of Pathology, Matermal and Child Health Hospital of Kunming, Kunrning 650031, China
- 2. Department of Gynecology, Matermal and Child Health Hospital of Kunming, Kunming 650031, China
- 3. Department of Pathology, The First Affiliated Hospital of Kunming Medical College, Kunming 650031, China
- 折叠
摘要
Abstract
Objective: To investigate vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) on the fibromyoma uteri treated with mifepristone. Methods: VEGF expression and MVD were counted on 60 cases of the fibromyoma uteri by SP method, including 40 cases of mifepristone treated and 20 cases of untreated patients as controlled group. Results: VEGF positive expression rate and MVD in treated group were 37.5% and 9.90 ± 5.95, which were lower than those in controlled group (60% and 16.36 ± 2.07; P < 0.05). Meanwhile, in treated group, those in marked shrink in tumor size sub-group were lower than in not obvious sub.group (12.0% and 7.89 ± 4.36 vs. 80% and 11.29 ± 3.10; P < 0.05). Conclusion: VEGF and MVD expression decreases in the flbromyoma uteri after treatment with mifepristone, suggesting that mifepristone could inhibit angiogenesis and blood supply resulting in tumor shrink.关键词
vascular endothelial growth factor (VEGF)/microvessel density (MVD)/mifepristone/fibromyoma uteriKey words
vascular endothelial growth factor (VEGF)/microvessel density (MVD)/mifepristone/fibromyoma uteri分类
医药卫生引用本文复制引用
Huaqing Wen,Jihong Deng,Ping Pu,Haitao Wang,Wei Yin..血管内皮生长因子、微血管密度在子宫平滑肌瘤中的表达意义[J].中德临床肿瘤学杂志(英文版),2008,7(10):593-596,4.
